This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal entitled """"""""The role of protein malnutrition on circadian physiology of C57BL/6J mouse dams and their offspring"""""""" aims to investigate the underlying role of desynchronized circadian rhythms after exposure of female mice to a protein deficient diet and the outcome of this expose to the circadian phenotype of the offspring. The process by which the intra-uterine environment plays a role in establishing the health of the offspring has been termed """"""""fetal programming"""""""". Maternal under-nutrition as well as other factors can lead to offspring that display inter-uterine growth retardation (IUGR) and have reduced birth weight. Through unknown mechanisms, maternal malnutrition in rodents has been associated with altered responses to hormones regulating food intake and energy expenditure leading to lifelong hyperphagia and an obesity that is associated with a diabetic phenotype. Prenatal exposure to a low protein diet is a commonly used model mimicking fetal under-nutrition, and when administered to rat dams, results in offspring exhibiting signs of Type II diabetes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR021945-05
Application #
8167954
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2010-07-01
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
5
Fiscal Year
2010
Total Cost
$213,145
Indirect Cost
Name
Lsu Pennington Biomedical Research Center
Department
Type
Organized Research Units
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808
Sarzynski, Mark A; Ruiz-Ramie, Jonathan J; Barber, Jacob L et al. (2018) Effects of Increasing Exercise Intensity and Dose on Multiple Measures of HDL (High-Density Lipoprotein) Function. Arterioscler Thromb Vasc Biol 38:943-952
Yu, Sangho; François, Marie; Huesing, Clara et al. (2018) The Hypothalamic Preoptic Area and Body Weight Control. Neuroendocrinology 106:187-194
Wanders, Desiree; Forney, Laura A; Stone, Kirsten P et al. (2018) The Components of Age-Dependent Effects of Dietary Methionine Restriction on Energy Balance in Rats. Obesity (Silver Spring) 26:740-746
François, Marie; Qualls-Creekmore, Emily; Berthoud, Hans-Rudolf et al. (2018) Genetics-based manipulation of adipose tissue sympathetic innervation. Physiol Behav 190:21-27
Kruger, Claudia; Burke, Susan J; Collier, J Jason et al. (2018) Lipid peroxidation regulates podocyte migration and cytoskeletal structure through redox sensitive RhoA signaling. Redox Biol 16:248-254
Yu, Sangho; Münzberg, Heike (2018) Testing Effects of Chronic Chemogenetic Neuronal Stimulation on Energy Balance by Indirect Calorimetry. Bio Protoc 8:
Forney, Laura A; Stone, Kirsten P; Wanders, Desiree et al. (2018) Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response. Front Neuroendocrinol 51:36-45
Costford, Sheila R; Brouwers, Bram; Hopf, Meghan E et al. (2018) Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance. Mol Metab 7:1-11
Burke, Susan J; Batdorf, Heidi M; Martin, Thomas M et al. (2018) Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels. Obesity (Silver Spring) 26:1188-1196
Poret, J M; Souza-Smith, F; Marcell, S J et al. (2018) High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats. Int J Obes (Lond) 42:535-541

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