Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Pathology and Metabolic Research Core Description The pathology and metabolic core provide technical services and support to participating investigators in the areas of tissue pathology, measurement of whole body metabolism in mice, and for metabolism studies for collection of urine/feces in mice where food and water intake are quantified. A major purpose of the core is to operate instrumentation for measurement of whole body metabolism in mice, for metabolism studies, and for pathology services on several tissue types. Supervised equipment includes a LabMaster Phenomaster TSE system (24 computer controlled cages), a LabMaster Metabolic Cage system (8 computer controlled cages), tissue processor, paraffin microtome, and microscope with image analysis software.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR021954-04
Application #
8360246
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
4
Fiscal Year
2011
Total Cost
$195,885
Indirect Cost

  Institution

Name
University of Kentucky
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Tannock, Lisa R; De Beer, Maria C; Ji, Ailing et al. (2018) Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein. J Lipid Res 59:339-347
Wahlang, Banrida; Barney, Jazmyne; Thompson, Brendan et al. (2017) Editor's Highlight: PCB126 Exposure Increases Risk for Peripheral Vascular Diseases in a Liver Injury Mouse Model. Toxicol Sci 160:256-267
Dong, Anping; Mueller, Paul; Yang, Fanmuyi et al. (2017) Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice. Thromb Res 159:58-64
Harfmann, Brianna D; Schroder, Elizabeth A; England, Jonathan H et al. (2017) Temperature as a Circadian Marker in Older Human Subjects: Relationship to Metabolic Syndrome and Diabetes. J Endocr Soc 1:843-851
Brown, J Mark; Temel, Ryan E; Graf, Gregory A (2017) Para-bile-osis Establishes a Role for Nonbiliary Macrophage to Feces Reverse Cholesterol Transport. Arterioscler Thromb Vasc Biol 37:738-739
Jiang, Jieyun; Creasy, Kate Townsend; Purnell, Justin et al. (2017) Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liver. J Biol Chem 292:6765-6774
Narayanaswami, Vidya; Dwoskin, Linda P (2017) Obesity: Current and potential pharmacotherapeutics and targets. Pharmacol Ther 170:116-147
Hager, Matthew R; Narla, Archana D; Tannock, Lisa R (2017) Dyslipidemia in patients with chronic kidney disease. Rev Endocr Metab Disord 18:29-40
Wu, Chia-Hua; Mohammadmoradi, Shayan; Thompson, Joel et al. (2016) Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male Mice. Hypertension 68:213-9
Creasy, Kate T; Jiang, Jieyun; Ren, Hui et al. (2016) Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver. Gene Expr 17:7-17

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