The goal of the Center of Biomedical Research Excellence (COBRE) is to establish a multi-disciplinary translational research center focusing on cartilage and joint health and disease mechanisms and developing repair strategy. The projects encompass clinical, biological, and engineering research fields. Projects 1 and2 analyze how long bones are built up during skeletal development. Projects 3 and 4 examine how joint cartilage degenerates in adult joint diseases. Project 5 studies how to repair and re-build healthy cartilage joint. The investigators and mentors are selected from five departments in Rhode Island Hospital/Brown Medical School (Orthopaedics, Pediatrics, Emergency Medicine, Medicine, and Bioengineering). The junior investigators include three clinician/scientists and two basic research scientists. The mentors also include both clinician/scientists and basic research scientists. Each mentor is a Principal Investigator of multiple federal grants (NIH RO1 or VA). They will supervise junior investigator's research projects, serve as their role models, and mentor them to obtain federal research project grants. Our vision is, by establishing this research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators with senior investigators, and biologists with bioengineers. This multi-disciplinary approach is absolutely necessary to develop translational strategies for prevention and treatment of skeletal joint diseases.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR024484-04
Application #
7895656
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Liu, Yanping
Project Start
2007-09-15
Project End
2012-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
4
Fiscal Year
2010
Total Cost
$2,090,744
Indirect Cost
Name
Rhode Island Hospital
Department
Type
DUNS #
075710996
City
Providence
State
RI
Country
United States
Zip Code
02903
Gil, Joseph A; Chambers, Alison; Shah, Kalpit N et al. (2018) A Biomechanical Evaluation of a 2-Suture Anchor Repair Technique for Thumb Metacarpophalangeal Joint Ulnar Collateral Ligament Injuries. Hand (N Y) 13:581-585
Nacca, Christopher; Gil, Joseph A; Badida, Rohit et al. (2018) Critical Glenoid Bone Loss in Posterior Shoulder Instability. Am J Sports Med 46:1058-1063
Mansuripur, P Kaveh; Gil, Joseph A; Cassidy, Dale et al. (2018) Fixation Strength in Full and Limited Fixation of Osteoporotic Distal Radius Fractures. Hand (N Y) 13:461-465
Larson, K M; Zhang, L; Badger, G J et al. (2017) Early genetic restoration of lubricin expression in transgenic mice mitigates chondrocyte peroxynitrite release and caspase-3 activation. Osteoarthritis Cartilage 25:1488-1495
Gil, Joseph A; Ebert, Kerry; Blanchard, Keri et al. (2017) Efficacy of a radial-based thumb metacarpophalangeal-stabilizing orthosis for protecting the thumb metacarpophalangeal joint ulnar collateral ligament. J Hand Ther :
Karamchedu, Naga Padmini; Tofte, Josef N; Waller, Kimberly A et al. (2016) Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysis. Arthritis Res Ther 18:64
Li, Pengcui; Deng, Jin; Wei, Xiaochun et al. (2016) Blockade of hypoxia-induced CXCR4 with AMD3100 inhibits production of OA-associated catabolic mediators IL-1? and MMP-13. Mol Med Rep 14:1475-82
Proffen, Benedikt L; Sieker, Jakob T; Murray, Martha M et al. (2016) Extracellular matrix-blood composite injection reduces post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat. J Orthop Res 34:995-1003
Teeple, Erin; Karamchedu, Naga Padmini; Larson, Katherine M et al. (2016) Arthroscopic irrigation of the bovine stifle joint increases cartilage surface friction and decreases superficial zone lubricin. J Biomech 49:3106-3110
Chin, K E; Karamchedu, N P; Patel, T K et al. (2016) Comparison of micro-CT post-processing methods for evaluating the trabecular bone volume fraction in a rat ACL-transection model. J Biomech 49:3559-3563

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