Rehabilitation crucially requires interaction with the nervous system. Thus, neuromodulation (NM) is a tool uniquely able to address a large number of conditions and populations through a set of common principles that underlie an emerging neural circuit-based approach to rehabilitation and medicine. Our foundational belief is that applying NM to specific networks offers outstanding promise for advancing and improving nearly all fields of rehabilitation. While having grown over the past five years, the field of NM for rehabilitation (NM4R ? the combination of NM and rehabilitation) is still nascent and is just beginning to clinically impact the practice of rehabilitation. The renewal of the National Center of Neuromodulation for Rehabilitation (NC NM4R) at the Medical University of South Carolina (MUSC) builds upon our early successes to facilitate the key steps in the discovery process that are required to develop the next generation of NM4R interventions and to use these tools to understand and study neuroplastic nervous system changes associated with rehabilitation. The center harnesses outstanding expertise in non-invasive NM, rehabilitation, operant conditioning of brain and spinal networks and animal models of NM4R. teams have formed a cohesive NM4R Community, returning to our center for multiple workshops and hands-on training experiential sessions, receiving follow-on consultations leading to pilot awards and extramural funding, and have publishing in peer-reviewed journals. The overarching goal over the new grant period is to impact multiple priorities of the NIH Research Plan for Rehabilitation (RPR) ? most notably to translational science, pediatric rehabilitation and research design and methodology ? by increasing rehabilitation research workforce access to NM4R approaches and supporting rigorous clinical research to translate them into effective, evidence-based rehabilitation interventions.
Our Specific Aims are to:
AIM 1. Increase the size and diversity of the rehabilitation research workforce with access to NM4R approaches;
and AIM 2. Increase the impact of NM4R approaches. In the proposed renewal, our center will design yearly strategic activities to focus on impacting RPR priorities. Adjacent fields such as psychiatry are more advanced in applying NM tools in an emerging circuit-based medical model. NC NM4R will serve a vital purpose by infusing NM skills throughout the rehabilitation workforce and ensuring early exposure to the cutting edge of NM research for rehabilitation researchers in all domains.

Public Health Relevance

The National Center of Neuromodulation for Rehabilitation (NC NM4R) at the Medical University of South Carolina (MUSC) addresses the critical need for focused rehabilitation research infrastructure to support rigorous clinical research and to translate non-invasive neuromodulation for rehabilitation reserach approaches into effective, evidence-based interventions. The Center has become an integrated system for training researchers across the spectrum from postdocs to senior investigators, enabling critical data collection via pilot awards, advancing careers and extramural grant applications through mentored collaborative consultations, convening world leaders in the field to discuss methods and technology, and enhancing rigor and reproducibility through hands-on workshops culminating in a research-ready workforce. In the renewal, we will enhance our strategies to closely align with the priority areas indentified in the NIH Research Plan for Rehabilitation.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Resource-Related Research Multi-Component Projects and Centers (P2C)
Project #
2P2CHD086844-06
Application #
9967709
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Bonner, Joseph Francis
Project Start
2015-09-15
Project End
2025-04-30
Budget Start
2020-07-01
Budget End
2021-04-30
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Other Health Professions
Type
Sch Allied Health Professions
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29407
Chhatbar, Pratik Y; Kautz, Steven A; Takacs, Istvan et al. (2018) Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo. Brain Stimul 11:727-733
Eftekhar, Amir; Norton, James J S; McDonough, Christine M et al. (2018) Retraining Reflexes: Clinical Translation of Spinal Reflex Operant Conditioning. Neurotherapeutics :
Alawieh, Ali; Andersen, Meredith; Adkins, DeAnna L et al. (2018) Acute Complement Inhibition Potentiates Neurorehabilitation and Enhances tPA-Mediated Neuroprotection. J Neurosci 38:6527-6545
Badran, Bashar W; Dowdle, Logan T; Mithoefer, Oliver J et al. (2018) Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (taVNS) via electrical stimulation of the tragus: A concurrent taVNS/fMRI study and review. Brain Stimul 11:492-500
Badran, Bashar W; Mithoefer, Oliver J; Summer, Caroline E et al. (2018) Short trains of transcutaneous auricular vagus nerve stimulation (taVNS) have parameter-specific effects on heart rate. Brain Stimul 11:699-708
Dowdle, Logan T; Brown, Truman R; George, Mark S et al. (2018) Single pulse TMS to the DLPFC, compared to a matched sham control, induces a direct, causal increase in caudate, cingulate, and thalamic BOLD signal. Brain Stimul 11:789-796
Grattan, Emily S; Skidmore, Elizabeth R; Woodbury, Michelle L (2018) Examining Anosognosia of Neglect. OTJR (Thorofare N J) 38:113-120
Alawieh, Ali; Zhao, Jing; Feng, Wuwei (2018) Factors affecting post-stroke motor recovery: Implications on neurotherapy after brain injury. Behav Brain Res 340:94-101
Summers, Philipp M; Hanlon, Colleen A (2017) BrainRuler-a free, open-access tool for calculating scalp to cortex distance. Brain Stimul 10:1009-1010
Chhatbar, Pratik Y; George, Mark S; Kautz, Steven A et al. (2017) Quantitative reassessment of safety limits of tDCS for two animal studies. Brain Stimul 10:1011-1012

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