The Neuropathology Core fulfills an essential role in the overall function of the Alzheimer's Disease Center (ADC). This Core is responsible for accessioning brains for autopsy and providing a neuropathological diagnosis. Semi-quantitative and quantitative information regarding the neuropathological examinations of demented patients and normal controls is also obtained. The Core is responsible for distributing biological tissue to investigators inside and outside the institution. Thus far, the autopsy rate from the Rochester community sample is 56%. The clinical neuropathologic correlation for both Rochester community patients and patients from the Jacksonville, Florida satellite has been good. The mean age at the time of death of patients from the community sample is 84 years, and consequently, issues regarding appropriate neuropathological criteria for dementia in this older age group will be studied by this Core. We anticipate processing approximately 20 brains per year from Rochester and 15 brains per year from the Jacksonville satellite. Through a collaborative arrangement, selected cases will be sent to Bradley Hyman, M.D., Ph.D. at the massachusetts General Hospital for further quantitative analysis of neuropathological markers i normal aging, patients with a mild cognitive impairment and patients with early AD. Brain tissue will continue to be sent to our basic neuroscience collaborators at Mayo Jacksonville. The Neuropathology Core is also processing and storing frozen lymphocytes for future DNA analysis. The Core is currently performing Apolipoprotein E analyses on demential cases and normal controls, and has accumulated a large series of specimens on longitudinally studied patients. The Core is also involved in entering its dat into the ADCs overall database. This process is in the formative stages currently and will be pursued in the proposed grant. In addition, i the next grant period the ADC would like to expand its neuropathological resources to the Jacksonville satellite to enable processing of postmortem tissue locally. The Neuropathology Core is performing an essential function for the ADC and is expanding its services. It will continue to provide basic neuropathological diagnostic information as well as serve as a resource for other investigators using biological material.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG008031-09S1
Application #
6098166
Study Section
Project Start
1998-08-01
Project End
1999-04-30
Budget Start
Budget End
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Jack Jr, C R; O'Brien, P C; Rettman, D W et al. (2001) FLAIR histogram segmentation for measurement of leukoaraiosis volume. J Magn Reson Imaging 14:668-76
Jack Jr, C R; Petersen, R C; Xu, Y et al. (2000) Rates of hippocampal atrophy correlate with change in clinical status in aging and AD. Neurology 55:484-89
Jack Jr, C R; Petersen, R C; Xu, Y C et al. (1999) Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology 52:1397-403
Leibson, C; Owens, T; O'Brien, P et al. (1999) Use of physician and acute care services by persons with and without Alzheimer's disease: a population-based comparison. J Am Geriatr Soc 47:864-9
Jack Jr, C R; Petersen, R C; Xu, Y et al. (1998) Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease. Neurology 51:993-9
Lucas, J A; Ivnik, R J; Smith, G E et al. (1998) Mayo's older Americans normative studies: category fluency norms. J Clin Exp Neuropsychol 20:194-200
Lucas, J A; Ivnik, R J; Smith, G E et al. (1998) Normative data for the Mattis Dementia Rating Scale. J Clin Exp Neuropsychol 20:536-47
Petersen, R C (1998) Clinical subtypes of Alzheimer's disease. Dement Geriatr Cogn Disord 9 Suppl 3:16-24
Jack Jr, C R; Petersen, R C; Xu, Y C et al. (1998) Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease. Ann Neurol 43:303-10
Ivnik, R J; Smith, G E; Lucas, J A et al. (1997) Free and cued selective reminding test: MOANS norms. J Clin Exp Neuropsychol 19:676-91

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