Abstract

The Neuropathology Core will coordinate post-mortem retrieval of brains from patients studied in the Clinical Core and will dissect and preserve these brains in an anatomically precise manner. This will permit application of multiple immunocytochemical, molecular biological and biochemical procedures to specific brain regions that also have been subjected to semi-quantitative histologic assessment of Alzheimer's disease abnormalities (senile plaques, neurofibrillary tangles, neuronal loss, abnormal neurites) using silver, tinctorial and immunostaining; measurement of senile plaque; differential counts of plaques by type; and biochemical assay of choline acetyltransferase and Alzheimer-related proteins. The results of the neuropathologic and biochemical assessments will be compared with each other and with clinical/neuroimaging assessments in order to assess diagnostic accuracy and identify neuropathologic indices of disease severity and localication that correlate with cognitive defects. These comparisons will test the accuracy of the assessments and provide to collaborating scientists large amounts of well studied brain tissue with a known type and degree of pathology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010129-04
Application #
3746136
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Gavett, Brandon E; Fletcher, Evan; Harvey, Danielle et al. (2018) Ethnoracial differences in brain structure change and cognitive change. Neuropsychology 32:529-540
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Sarnowski, Chloé; Satizabal, Claudia L; DeCarli, Charles et al. (2018) Whole genome sequence analyses of brain imaging measures in the Framingham Study. Neurology 90:e188-e196
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Gilsanz, Paola; Mayeda, Elizabeth Rose; Glymour, M Maria et al. (2018) Birth in High Infant Mortality States and Dementia Risk in a Cohort of Elderly African American and White Health Care Members. Alzheimer Dis Assoc Disord :
Mungas, Dan; Early, Dawnté R; Glymour, M Maria et al. (2018) Education, bilingualism, and cognitive trajectories: Sacramento Area Latino Aging Study (SALSA). Neuropsychology 32:77-88
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826
Meyer, Oanh L; Mungas, Dan; King, Jesse et al. (2018) Neighborhood Socioeconomic Status and Cognitive Trajectories in a Diverse Longitudinal Cohort. Clin Gerontol 41:82-93
Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360

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