Abstract

- Neuroimaging Core The Neuroimaging Core (NC) plays an integral role in the UC Davis ADC (UCD ADC) scientific mission by providing imaging-based biological markers of disease processes in brain structure and function. In vivo imaging of cerebral pathology and brain status provides measures that are central to the overarching scientific theme of the UCD ADC which seeks to use demographic diversity to understand the multiple life course factors that influence brain and cognitive trajectories in old age and transitions to dementia. Building on the success of our previous cycles of funded activities, the NC will continue to provide a comprehensive and expanded set of neuroimaging services ranging from image acquisition and storage to post-processing, creation of standard and customized analytic data sets, and dissemination of imaging data. In addition, the NC will continue to collaborate with other neuroimaging institutions as well as researchers at UC Davis to develop novel state-of- the-art methods for measuring the natural course of late-life brain injury.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010129-30
Application #
9978585
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
30
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Lian, Chunfeng; Liu, Mingxia; Zhang, Jun et al. (2018) Automatic Segmentation of 3D Perivascular Spaces in 7T MR Images Using Multi-Channel Fully Convolutional Network. Proc Int Soc Magn Reson Med Sci Meet Exhib Int Soc Magn Reson M 2018:
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Rangaraju, Srikant; Dammer, Eric B; Raza, Syed Ali et al. (2018) Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease. Mol Neurodegener 13:24
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Chen, Yi-Je; Nguyen, Hai M; Maezawa, Izumi et al. (2018) Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Ann Clin Transl Neurol 5:147-161
Di Lucente, Jacopo; Nguyen, Hai M; Wulff, Heike et al. (2018) The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo. Glia 66:1881-1895
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307

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