Core-- Neuropathology

Mirra, Suzanne S.

Abstract

The Neuropathology Core will facilitate research on Alzheimer's disease (AD) by providing diagnostic and comprehensive neuropathological assessment on autopsy brains from well characterized patients and control subjects. Particular emphasis will be placed on characterization of the neuropathological heterogeneity of AD and its overlap with Parkinson's disease and other neurodegenerative disorders. Information on the neuropathological basis of dementia in the understudied African American population will be sought as clinical and educational outreach programs of the Alzheimer's Disease Center emphasize the importance of the autopsy. Through the maintenance of a 24 hour autopsy service and brain bank, the Neuropathology Core will supply brain tissue and other materials to the growing number of investigators at Emory involved in ongoing and new research studies. Neuropathology information will be maintained in a secure data base and integrated with data generated by the Clinical and Molecular Biology Cores.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Center Core Grants (P30)
• Project #: 2P30AG010130-06
• Application #: 5204743
• Support Year: 6
• Fiscal Year: 1996

Publications

Goldstein, Felicia C; Levey, Allan I; Steenland, N Kyle (2013) High blood pressure and cognitive decline in mild cognitive impairment. J Am Geriatr Soc 61:67-73

Procaccio, Vincent; Salazar, Gloria; Ono, Shoichiro et al. (2006) A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia. Am J Hum Genet 78:947-60

Goldstein, F C; Ashley, A V; Freedman, L J et al. (2005) Hypertension and cognitive performance in African Americans with Alzheimer disease. Neurology 64:899-901

Choi, Joungil; Levey, Allan I; Weintraub, Susan T et al. (2004) Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J Biol Chem 279:13256-64

Weiner, David M; Goodman, Matilda W; Colpitts, Tonya M et al. (2004) Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias. Am J Pharmacogenomics 4:119-28

Cairns, Nigel J; Zhukareva, Victoria; Uryu, Kunihiro et al. (2004) alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease. Am J Pathol 164:2153-61

Scherzer, Clemens R; Offe, Katrin; Gearing, Marla et al. (2004) Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol 61:1200-5

Cairns, Nigel J; Uryu, Kunihiro; Bigio, Eileen H et al. (2004) alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases. Acta Neuropathol (Berl) 108:213-23

Cairns, N J; Grossman, M; Arnold, S E et al. (2004) Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease. Neurology 63:1376-84

Gearing, Marla; Juncos, Jorge L; Procaccio, Vincent et al. (2002) Aggregation of actin and cofilin in identical twins with juvenile-onset dystonia. Ann Neurol 52:465-76