Abstract

The purpose of the Clinical core is to evaluate and carefully diagnose a population of patients with Alzheimer's disease, and other dementias, together with normal age-matched control subjects. Standard diagnostic criteria of DSM-III-R will be used for the diagnosis of dementia with NINCD/ADRDA criteria applied for the diagnosis of Alzheimer's disease. Severity of dementia will be graded according to Washington University criteria. Information will be gathered using the CERAD format and the CAMDEX structured interview. A particular emphasis will be to recruit and involve subjects of Afro- American ancestry. The use of CAMDEX or CERAD has not been validated in this population, so determination of these instruments' reliability will be one of our initial tasks. An emphasis will also be given to identifying patients with familial Alzheimer's disease, especially Afro-American kindreds, which have been rarely studied. Identification of Afro-American pedigrees for genetic linkage studies should be useful in determining the racial origin of the Alzheimer's disease gene. The Clinical Core will facilitate the development of new diagnostic algorithms, risk factor analysis instruments, neuroimaging studies, as well as other future pilot studies for improved assessment of dementia subjects and future research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010133-04
Application #
3746142
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Khan, Sikandar; Biju, Ashok; Wang, Sophia et al. (2018) Mobile critical care recovery program (m-CCRP) for acute respiratory failure survivors: study protocol for a randomized controlled trial. Trials 19:94
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Cong, Shan; Risacher, Shannon L; West, John D et al. (2018) Volumetric comparison of hippocampal subfields extracted from 4-minute accelerated vs. 8-minute high-resolution T2-weighted 3T MRI scans. Brain Imaging Behav 12:1583-1595
Brelstaff, Jack; Tolkovsky, Aviva M; Ghetti, Bernardino et al. (2018) Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell Rep 24:1939-1948.e4
Miller, Jason E; Shivakumar, Manu K; Risacher, Shannon L et al. (2018) Codon bias among synonymous rare variants is associated with Alzheimer's disease imaging biomarker. Pac Symp Biocomput 23:365-376
Swinford, Cecily G; Risacher, Shannon L; Charil, Arnaud et al. (2018) Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition. Alzheimers Dement (Amst) 10:322-331
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27

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