Abstract

Alzheimer's disease is characterized by deficits in learning and memory. Hippocampal NMDA and non-NMDA (kianate and quisqualate) glutamate receptors have been implicated in the acquisition and storage of memory. Interestingly, both NMDA and quisqualate hippocampal receptors are significantly reduced in Alzheimer's disease patients. This suggests that glutamate dysfunction may be an important component in the expression of Alzheimer's disease symptomatology. We hypothesize that quisqualate mediated phospholipase C activity is decreased in Alzheimer's disease and that this results in impaired cellular function. To test this hypothesis, quisqualate stimulated IP3, protein kinase C activity and distribution ill be examined in Alzheimer's patients and non-Alzheimer's control patients. These studies will determine whether the loss of hippocampal glutamate receptors observed in Alzheimer's disease can be functionally correlated with a loss of glutamate induced neuronal activation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG012300-03
Application #
5204952
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17
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