Abstract

The Statistics and Data Management Core is a dedicated group of statistical and database personnel whose expertise supports research in normal aging, Alzheimer's disease and related dementias at U.T. Southwestern (UTSW) and for national (National Alzheimer's Coordinating Center) and state efforts (Texas Alzheimer's Research Consortium).
The Specific Aims of the Statistics and Data Management Core are: (1). Provide statistical and data management support for investigators, fellows and graduate students doing research in normal aging, Alzheimer's disease and related dementias as well as training for those researchers in the design and analysis of clinical studies. Participate in study development, analyses, posters and manuscripts. ( 2). Statistics and data base support. Statisticians with biomarker analysis expertise will provide analyses using state of the art techniques. Analyses of imaging data will involve collaboration with our colleagues in the Clinical Core using specialized techniques they have developed. (3). Participate in national and state efforts related to normal aging, Alzheimer's disease and related dementias. We submit our subject data to NACC on a regular and timely basis. Our Core continues to provide leadership at the national level: Joe Webster served on an advisory committee in the early years and Joan Reisch was selected as a member of the first Data Advisory Board for NACC. Currently Dr. Linda Hynan serves on the NACC Publications committee (2009-2011);Dr. Reisch participates in the semi-annual meetings of ADC directors.

Public Health Relevance

The development of successful therapies for Alzheimer's disease (AD) will require a thorough understanding of the pathologic mechanisms that contribute to neurodegeneration. Data from epidemiologic and observational studies indicates that vascular and inflammatory pathology contributes to AD. The goal of the UTSW ADC is to identify biomarkers of vascular and inflammatory pathology that will be useful for selection of participants in clinical trials.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG012300-19
Application #
8501180
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
19
Fiscal Year
2013
Total Cost
$198,248
Indirect Cost
$73,564

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

LoBue, Christian; Woon, Fu L; Rossetti, Heidi C et al. (2018) Traumatic brain injury history and progression from mild cognitive impairment to Alzheimer disease. Neuropsychology 32:401-409
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Rosenberg, Roger N; Fu, Min; Lambracht-Washington, Doris (2018) Active full-length DNA A?42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology. Alzheimers Res Ther 10:115
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Rosenberg, Roger N; Fu, Min; Lambracht-Washington, Doris (2018) Intradermal active full-length DNA A?42 immunization via electroporation leads to high anti-A? antibody levels in wild-type mice. J Neuroimmunol 322:15-25
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27

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