Abstract

SPECIFIC AIMS The proposed Functional Genomics Core is an evolution of our Gene Expression Core. The past four years has seen an explosion of technology for genomics. The ability to survey expression of large parts of the genome is likely to be important for understanding the basic biology of aging.
The specific aims of the core are to facilitate access by our biology of aging faculty to transcriptomics, metabolomics and proteomics technologies in a manner that will be most efficient and scientifically productive.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013280-14
Application #
7651128
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
14
Fiscal Year
2008
Total Cost
$301,230
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Walters, Ryan O; Arias, Esperanza; Diaz, Antonio et al. (2018) Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. Cell Rep 25:663-676.e6
Kramer, Philip A; Duan, Jicheng; Gaffrey, Matthew J et al. (2018) Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. Redox Biol 17:367-376
Kaeberlein, Matt (2018) How healthy is the healthspan concept? Geroscience 40:361-364
Crane, Matthew M; Kaeberlein, Matt (2018) The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells. Curr Opin Syst Biol 8:25-31
Beaupere, Carine; Dinatto, Leticia; Wasko, Brian M et al. (2018) Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A 115:9586-9591
Andeen, Nicole K; Yang, Han-Yin; Dai, Dao-Fu et al. (2018) DnaJ Homolog Subfamily B Member 9 Is a Putative Autoantigen in Fibrillary GN. J Am Soc Nephrol 29:231-239
Bennett, Christopher F; Kwon, Jane J; Chen, Christine et al. (2017) Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans. PLoS Genet 13:e1006695
Mukherjee, Shubhabrata; Russell, Joshua C; Carr, Daniel T et al. (2017) Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments. Alzheimers Dement 13:1133-1142
Miller, Hillary; Fletcher, Marissa; Primitivo, Melissa et al. (2017) Genetic interaction with temperature is an important determinant of nematode longevity. Aging Cell 16:1425-1429
Martin-Perez, Miguel; Villén, Judit (2017) Determinants and Regulation of Protein Turnover in Yeast. Cell Syst 5:283-294.e5

Showing the most recent 10 out of 168 publications