Abstract

SPECIFIC AIMS 1. Continue to develop new genetically altered animal models for studying mechanisms of the biology of aging. 2. Provide a resource that enables University of Washington Health Sciences faculty involved in various aging projects to utilize genetic engineering technology for answering basic questions about the biology of aging. 3. Provide a resource and expertise in the construction of targeting vectors, injectable DNA constructs and inducible promoters systems for generating genetically altered animal models of the biology of aging. 4. Accelerate and enhance cryopreservation of embryos and sperm from useful genetically altered mouse models of aging for repository storage and conservation of housing resources. 5. Provide a training resource for fellows and junior faculty in transgenic and embryonic stem cell technology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013280-15
Application #
7899974
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
15
Fiscal Year
2009
Total Cost
$408,243
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Walters, Ryan O; Arias, Esperanza; Diaz, Antonio et al. (2018) Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. Cell Rep 25:663-676.e6
Kramer, Philip A; Duan, Jicheng; Gaffrey, Matthew J et al. (2018) Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. Redox Biol 17:367-376
Kaeberlein, Matt (2018) How healthy is the healthspan concept? Geroscience 40:361-364
Crane, Matthew M; Kaeberlein, Matt (2018) The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells. Curr Opin Syst Biol 8:25-31
Beaupere, Carine; Dinatto, Leticia; Wasko, Brian M et al. (2018) Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A 115:9586-9591
Andeen, Nicole K; Yang, Han-Yin; Dai, Dao-Fu et al. (2018) DnaJ Homolog Subfamily B Member 9 Is a Putative Autoantigen in Fibrillary GN. J Am Soc Nephrol 29:231-239
Urfer, Silvan R; Kaeberlein, Tammi L; Mailheau, Susan et al. (2017) Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging. Geroscience 39:43-50
Mendenhall, Alexander; Crane, Matthew M; Leiser, Scott et al. (2017) Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 72:1033-1037
Beaupere, Carine; Wasko, Brian M; Lorusso, Jared et al. (2017) CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell Rep 18:1884-1892
Urfer, Silvan R; Kaeberlein, Tammi L; Mailheau, Susan et al. (2017) A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. Geroscience 39:117-127

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