This application is for renewal of the Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington and affiliated institutions. This Center has over the past 20 years provided key resources in support of investigators who study the biology of aging. This application shifts to a theme that emphases outreach and service to the broadest community of investigators in the gerosciences. Of proximal relevance is the focus on characterizing aging-related phenotypes of longevity and healthspan. As our Center services must be easily accessible to outside users, our Longevity and Healthspan Core C focuses on invertebrate assays, many of them novel. Two other Research Resources focus on the high dimensional assessments that are most directly related to aging phenotypes, Protein Phenotypes of Aging (Core A) and Metabolite Phenotypes of Aging (Core B). Each of these three Resource Cores is led by a highly respected expert in that field, Michael MacCoss (Core A), Daniel Promislow (Core B) and Matt Kaeberlein (Core C). Each will push the envelope of appropriate technologies, developing new state-of-the art approaches for assessments that are the most applicable to gerontology and making them accessible to the aging community. The Research Development Core will support pilot projects, with an emphasis on support and career development of junior investigators, focusing on projects that can capitalize on the strengths of our Research Resource Core services. To broaden our outreach, the majority of awards will be to investigators outside our region. The Program Enrichment Core supports administrative management, an external advisory panel, a program of courses and seminars, data sharing and dissemination and advanced informatics and biostatistical support. A program of workshops will be focused on the fields of our three Research Resource Cores, to most fully integrate and disseminate the strengths of our Center.

Public Health Relevance

The goal of this program is to enhance the ability of investigators nationwide to study the basic biology of aging, utilizing state-of-the-art research resources and providing the strongest possible environment for education, communication and research development. Understanding the basis of aging will ultimately help prevent the debilitating diseases of aging and improve the health of the elderly population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013280-24
Application #
9521970
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Sierra, Felipe
Project Start
1997-07-15
Project End
2020-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
24
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Washington
Department
Pathology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Walters, Ryan O; Arias, Esperanza; Diaz, Antonio et al. (2018) Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. Cell Rep 25:663-676.e6
Kramer, Philip A; Duan, Jicheng; Gaffrey, Matthew J et al. (2018) Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. Redox Biol 17:367-376
Kaeberlein, Matt (2018) How healthy is the healthspan concept? Geroscience 40:361-364
Crane, Matthew M; Kaeberlein, Matt (2018) The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells. Curr Opin Syst Biol 8:25-31
Beaupere, Carine; Dinatto, Leticia; Wasko, Brian M et al. (2018) Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A 115:9586-9591
Andeen, Nicole K; Yang, Han-Yin; Dai, Dao-Fu et al. (2018) DnaJ Homolog Subfamily B Member 9 Is a Putative Autoantigen in Fibrillary GN. J Am Soc Nephrol 29:231-239
Urfer, Silvan R; Kaeberlein, Tammi L; Mailheau, Susan et al. (2017) Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging. Geroscience 39:43-50
Mendenhall, Alexander; Crane, Matthew M; Leiser, Scott et al. (2017) Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 72:1033-1037
Beaupere, Carine; Wasko, Brian M; Lorusso, Jared et al. (2017) CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell Rep 18:1884-1892
Urfer, Silvan R; Kaeberlein, Tammi L; Mailheau, Susan et al. (2017) A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. Geroscience 39:117-127

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