Abstract

CORE F: ARTIFICIAL INTELLIGENCE AND BIOINFORMATICS ? SUMMARY/ABSTRACT This Core will meet two major unmet needs for our Nathan Shock Center and the geroscience community at large. First, we will offer integrated statistical and bioinformatics consulting for all Center-supported projects from experimental design through to publication. This ensures that our Center resources have the greatest opportunity to support high-impact studies in aging research and also meets an important goal of enhancing rigor and reproducibility in biomedical research. Second, we will bring state-of-the-art computational approaches, particularly in the area of Artificial Intelligence (AI), to support Center users and maximize the impact of the other Resource Cores.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG013280-26
Application #
10042623
Study Section
Special Emphasis Panel (ZAG1)
Project Start
1997-07-15
Project End
2025-05-31
Budget Start
2020-09-01
Budget End
2021-05-31
Support Year
26
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Walters, Ryan O; Arias, Esperanza; Diaz, Antonio et al. (2018) Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. Cell Rep 25:663-676.e6
Kramer, Philip A; Duan, Jicheng; Gaffrey, Matthew J et al. (2018) Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. Redox Biol 17:367-376
Kaeberlein, Matt (2018) How healthy is the healthspan concept? Geroscience 40:361-364
Crane, Matthew M; Kaeberlein, Matt (2018) The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells. Curr Opin Syst Biol 8:25-31
Beaupere, Carine; Dinatto, Leticia; Wasko, Brian M et al. (2018) Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A 115:9586-9591
Andeen, Nicole K; Yang, Han-Yin; Dai, Dao-Fu et al. (2018) DnaJ Homolog Subfamily B Member 9 Is a Putative Autoantigen in Fibrillary GN. J Am Soc Nephrol 29:231-239
Beaupere, Carine; Wasko, Brian M; Lorusso, Jared et al. (2017) CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell Rep 18:1884-1892
Urfer, Silvan R; Kaeberlein, Tammi L; Mailheau, Susan et al. (2017) A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. Geroscience 39:117-127
Kapahi, Pankaj; Kaeberlein, Matt; Hansen, Malene (2017) Dietary restriction and lifespan: Lessons from invertebrate models. Ageing Res Rev 39:3-14
Lee, Mitchell B; Carr, Daniel T; Kiflezghi, Michael G et al. (2017) A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae. Geroscience 39:419-428

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