Core - Research Development

Abstract

The goal of the Research Development Core is to provide an environment for research fellows and junior faculty to obtain research training in the basic biology of aging. Existing and recruited candidates will be provided protected time through the Research Development Core program to conduct their research training. This will be done through salary support and the awarding of peer-reviewed pilot projects, in addition to participation in the proposed core resources. The Research Development Core will utilize a multidisciplinary approach in order to maximize interactions in the fields of biochemistry, molecular biology, immunology, neuroscience, pathology, and pharmacology.
The Specific Aims of this Core are to 1) identify exceptional research fellows and junior faculty who will be supported by the Research Development Core, and who have a strong research interest in the biology of aging, 2) establish a program by which these newly identified junior faculty can be developed into independent researchers in the area of aging, 3) establish a program by which junior faculty can submit proposals for pilot projects to support their research, and 4) identify senior faculty in the AHERF system who will serve as mentors to assist in the development of these junior faculty into independent investigators.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Center Core Grants (P30)
• Project #: 1P30AG013282-02S1
• Application #: 2778387
• Budget Start: 1997-10-01
• Budget End: 1998-09-30
• Support Year: 2
• Fiscal Year: 1998

Institution

• Name: Allegheny University of Health Sciences
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19129

Publications

Ray, Donna; Wu, Ailing; Wilkinson, J Erby et al. (2006) Aging in heterozygous Dnmt1-deficient mice: effects on survival, the DNA methylation genes, and the development of amyloidosis. J Gerontol A Biol Sci Med Sci 61:115-24

Mo, RuRan; Chen, Jun; Grolleau-Julius, Annabelle et al. (2005) Estrogen regulates CCR gene expression and function in T lymphocytes. J Immunol 174:6023-9

Mo, Ruran; Chen, Jun; Han, Yin et al. (2003) T cell chemokine receptor expression in aging. J Immunol 170:895-904

Chen, Jun; Mo, Ruran; Lescure, Pascal A et al. (2003) Aging is associated with increased T-cell chemokine expression in C57BL/6 mice. J Gerontol A Biol Sci Med Sci 58:975-83

Lorenzini, Antonello; Tresini, Maria; Mawal-Dewan, Madhu et al. (2002) Role of the Raf/MEK/ERK and the PI3K/Akt(PKB) pathways in fibroblast senescence. Exp Gerontol 37:1149-56

Yung, R; Ray, D; Eisenbraun, J K et al. (2001) Unexpected effects of a heterozygous dnmt1 null mutation on age-dependent DNA hypomethylation and autoimmunity. J Gerontol A Biol Sci Med Sci 56:B268-76

Tresini, M; Lorenzini, A; Frisoni, L et al. (2001) Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast. Exp Cell Res 269:287-300

Lorenzini, A; Hrelia, S; Bordoni, A et al. (2001) Is increased arachidonic acid release a cause or a consequence of replicative senescence? Exp Gerontol 36:65-78

Severino, J; Allen, R G; Balin, S et al. (2000) Is beta-galactosidase staining a marker of senescence in vitro and in vivo? Exp Cell Res 257:162-71

Li, M; Walter, R; Torres, C et al. (2000) Impaired signal transduction in mitogen activated rat splenic lymphocytes during aging. Mech Ageing Dev 113:85-99