The Cellular Imaging Core is designed to enhance the gerontological research capabilities of members of the Nathan Shock of Excellence by giving them access to contemporary imaging technologies and working with them to ensure that the appropriate technology is applied to their specific research problems.
Specific aims of the Core are 1) to provide facilities and instrumentation for high level image acquisition and analysis, 2) to provide technical assistance in the image acquisition process, 3) to assist Center investigators in the effective design of experiments and the interpretation of resulting of imaging, 4) to introduce non-morphologist members of the Shock Center to the capabilities of cellular imaging techniques and the specific instrumentation of the Cellular imaging techniques and the specific instrumentation of the Cellular Imaging Core, and 5) to facilitate and promote research on aging by providing access to the Imaging Core to collaborators of Shock Center investigators. The Imaging Core is well equipped with up to date microscopes, computers and digital output devices. Major instrumentation includes transmission and scanning electron microscopes, confocal and fluorescence microscopes, ultramicrotomes and other tissue preparation instruments, numerous computers, scanners and printers. The Cellular Imaging Core is an integral component of the Cell Biology Laboratories (CBL), a University microscopy core facility located in the Department of Anatomy and Cell Biology. The CBL, which has been existence for almost 20 years, is served by a manager, an engineer, a microscopy technician and a computer consultant. It is administered through the Department of Anatomy and Cell Biology. The CBL, which has been existence for almost 20 years, is served by a manager, an engineer, a microscopy technician and a computer consultant. It is administered through the Department of Anatomy and Cell Biology. Twenty three members of the Shock Center are current users of this core.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG013283-08S1
Application #
6615148
Study Section
Project Start
2002-08-01
Project End
2003-06-30
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Xiong, Yi; Torsoni, Adriana Souza; Wu, Feihua et al. (2018) Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. Elife 7:
Liu, Yan; Jiang, Lin; Sun, Chengxin et al. (2018) Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. Nat Commun 9:2751
Ghosh, Amiya Kumar; Mau, Theresa; O'Brien, Martin et al. (2018) Novel role of autophagy-associated Pik3c3 gene in gonadal white adipose tissue browning in aged C57/Bl6 male mice. Aging (Albany NY) 10:764-774
Shen, Hong; Sheng, Liang; Xiong, Yi et al. (2017) Thymic NF-?B-inducing kinase regulates CD4+ T cell-elicited liver injury and fibrosis in mice. J Hepatol 67:100-109
Julius, Annabelle; Desai, Anjali; Yung, Raymond L (2017) Recombinant human erythropoietin stimulates melanoma tumor growth through activation of initiation factor eIF4E. Oncotarget 8:30317-30327
Kim, Evelyn H; Galchev, Vladimir I; Kim, Jin Young et al. (2016) Differential protein expression and basal lamina remodeling in human heart failure. Proteomics Clin Appl 10:585-96
Ghosh, Amiya Kumar; Mau, Theresa; O'Brien, Martin et al. (2016) Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue. Aging (Albany NY) 8:2525-2537
Feinstein, Lydia; Ferrando-Martínez, Sara; Leal, Manuel et al. (2016) Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status. Biodemography Soc Biol 62:208-21
Figueroa-Romero, Claudia; Hur, Junguk; Lunn, J Simon et al. (2016) Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms. Mol Cell Neurosci 71:34-45
Sharma, Naveen; Arias, Edward B; Cartee, Gregory D (2016) Inhibition of Akt2 phosphorylation abolishes the calorie restriction-induced improvement in insulin-stimulated glucose uptake by rat soleus muscle. Appl Physiol Nutr Metab 41:1208-1211

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