Abstract

Drosophila Aging Core: Scott Pletcher, Director The DAC will serve the needs of three broad classes of users. (1) It will provide advice, technical assistance, and specialized facilities to Drosophila experts new to aging research. Such a user might, for example, be an expert on Drosophila development or muscle biology or circadian rhythmicity who wishes to evaluate mutants or drugs of interest in the context of aging. (2) It will tutor and collaborate with experienced biogerontologists, new to work on flies, who now wish to exploit the genetic potential of Drosophila to test molecular hypotheses or screen for mutants or drugs with specific properties of interest. (3) It will provide highly specialized protocols and equipment to support sophisticated studies of aging flies that would be difficult to conduct in less sophisticated facilities. The DAC will in particular support collaborations that depend on nutrient and odor manipulations, high throughput functional assays, and tests for organ-specific function that few individual laboratories can muster but that are appropriate for a national or regional resource.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG013283-16
Application #
8122847
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2 (M1))
Project Start
2010-07-01
Project End
2015-06-30
Budget Start
2010-08-15
Budget End
2011-06-30
Support Year
16
Fiscal Year
2010
Total Cost
$78,245
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Xiong, Yi; Torsoni, Adriana Souza; Wu, Feihua et al. (2018) Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. Elife 7:
Liu, Yan; Jiang, Lin; Sun, Chengxin et al. (2018) Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. Nat Commun 9:2751
Ghosh, Amiya Kumar; Mau, Theresa; O'Brien, Martin et al. (2018) Novel role of autophagy-associated Pik3c3 gene in gonadal white adipose tissue browning in aged C57/Bl6 male mice. Aging (Albany NY) 10:764-774
Shen, Hong; Sheng, Liang; Xiong, Yi et al. (2017) Thymic NF-?B-inducing kinase regulates CD4+ T cell-elicited liver injury and fibrosis in mice. J Hepatol 67:100-109
Julius, Annabelle; Desai, Anjali; Yung, Raymond L (2017) Recombinant human erythropoietin stimulates melanoma tumor growth through activation of initiation factor eIF4E. Oncotarget 8:30317-30327
Kim, Evelyn H; Galchev, Vladimir I; Kim, Jin Young et al. (2016) Differential protein expression and basal lamina remodeling in human heart failure. Proteomics Clin Appl 10:585-96
Ghosh, Amiya Kumar; Mau, Theresa; O'Brien, Martin et al. (2016) Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue. Aging (Albany NY) 8:2525-2537
Feinstein, Lydia; Ferrando-Martínez, Sara; Leal, Manuel et al. (2016) Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status. Biodemography Soc Biol 62:208-21
Figueroa-Romero, Claudia; Hur, Junguk; Lunn, J Simon et al. (2016) Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms. Mol Cell Neurosci 71:34-45
Sharma, Naveen; Arias, Edward B; Cartee, Gregory D (2016) Inhibition of Akt2 phosphorylation abolishes the calorie restriction-induced improvement in insulin-stimulated glucose uptake by rat soleus muscle. Appl Physiol Nutr Metab 41:1208-1211

Showing the most recent 10 out of 219 publications