The Biometry Core will provide data management and biostatistical consultation to cores within the NSC, particularly to the Animal, Pathology and Expression Profiling Cores. In collaboration with the Expression Profiling Core, the core will provide analysis of microarray data including hierarchical cluster analysis, self-organizing maps or principal components analysis. The necessary software to perform such analyses has been/will be obtained. The core also proposes to develop and maintain databases for the Center, including design and administration, development of data entry and tracking systems, and quality control systems, and monitoring functions primarily for the Animal and Pathology Cores. The consultation arm of the core will provide a needed base of expertise for young faculty and other investigators that will include participation in grant and manuscript submission, experimental design, data interpretation and analysis ad graphical representation of data. The NSC is currently conducting a search for an assistant professor in biostatistics/bioinformatics. Meanwhile, Dr. Nelson is serving as interim director and Dr. Hilsenbeck (Baylor) is serving in a collaborative capacity. The core has computer hardware to support the proposed research and to make future bioinformatics software available to NSC investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013319-08
Application #
6606013
Study Section
Special Emphasis Panel (ZAG1)
Project Start
2002-07-01
Project End
2003-06-30
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Gelfond, Jonathan; Goros, Martin; Hernandez, Brian et al. (2018) A System for an Accountable Data Analysis Process in R. R J 10:6-21
Sills, Aubrey M; Artavia, Joselyn M; DeRosa, Brian D et al. (2018) Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. Am J Primatol :e22927
Xu, Ming; Pirtskhalava, Tamar; Farr, Joshua N et al. (2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246-1256
Unnikrishnan, Archana; Hadad, Niran; Masser, Dustin R et al. (2018) Revisiting the genomic hypomethylation hypothesis of aging. Ann N Y Acad Sci 1418:69-79
Van Skike, Candice E; Jahrling, Jordan B; Olson, Angela B et al. (2018) Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol 314:H693-H703
Mao, Kai; Quipildor, Gabriela Farias; Tabrizian, Tahmineh et al. (2018) Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun 9:2394
Lee, Hak Joo; Feliers, Denis; Barnes, Jeffrey L et al. (2018) Hydrogen sulfide ameliorates aging-associated changes in the kidney. Geroscience 40:163-176
Kang, Donghoon; Kirienko, Daniel R; Webster, Phillip et al. (2018) Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. Virulence 9:804-817
Hook, Michael; Roy, Suheeta; Williams, Evan G et al. (2018) Genetic cartography of longevity in humans and mice: Current landscape and horizons. Biochim Biophys Acta Mol Basis Dis 1864:2718-2732
Van Skike, Candice E; Galvan, Veronica (2018) A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review. Gerontology 64:205-211

Showing the most recent 10 out of 231 publications