The Administrative/Program Enrichment Core is the organizational unit responsible for facilitating research in the basic biology of aging throughout the San Antonio (SA) Nathan Shock Center. The goal of the Core is to provide continuous leadership and infrastructure that catalyzes scientific discoveries, promotes education and research career development, and partners with other scientists and the community at large. The Administrative/Program Enrichment Core will foster and promote transformative research in geroscience using a comprehensive research platform that integrates studies on longevity (lifespan), integrated physiology (healthspan), pathology, and molecular phenotypes. These studies will drive discovery of molecular and cellular mechanisms that influence aging and the development of novel strategies (including the identification of pharmacologic targets) to promote healthy lifespan. The Administrative Core will monitor, stimulate, sustain, evaluate, and report progress toward our goals through the following Specific Aims: 1. To provide administrative, budgetary, and regulatory management support for the overall center; 2. To foster education and an environment that stimulates collaborative efforts and synergies among research resource cores and promotes education and research career development of early-career investigators; 3. To promote interactions in aging research through the sharing of core services with investigators at other institutions and building collaborations with other Nathan Shock Centers; 4. To provide biostatistical support to all core users, and data management and project tracking for each of the resource cores; 5. To conduct continuous internal evaluations of the center and periodic external evaluations. Innovation: To further the continuing development of our center's research programs, the Administrative Core will incorporate innovative features including: (1) An innovative web-based project management system to promote efficient monitoring and reporting of project outcomes and to stimulate collaboration on the analysis of projects supported by the resource cores; (2) Novel statistical methodology to analyze complex outcomes and phenotypes relevant to aging research; (3) Facilitation of webinars to be run by the core leaders; as part of the educational and training goals of the center, webinars will explain and promote the services that can be offered by each core. The Core will lead to three kinds of progress. First, it will foster a cooperative research environment within UTHSCSA that will attract investigators to aging research via specific educational programs (i.e., seminars, faculty and student retreats, and symposia that focus on various aspects of aging). Second, it will foster external collaborative efforts with other Nathan Shock Centers. Third, it will assist with development and expansion of aging research at other institutions with fewer resources for biology of aging research compared with UTHSCSA.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG013319-26
Application #
10045448
Study Section
Special Emphasis Panel (ZAG1)
Project Start
1997-07-15
Project End
2025-05-31
Budget Start
2020-09-01
Budget End
2021-05-31
Support Year
26
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Texas Health Science Center
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Salmon, Adam B; Dorigatti, Jonathan; Huber, Hillary F et al. (2018) Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions. Geroscience 40:269-278
Gelfond, Jonathan; Goros, Martin; Hernandez, Brian et al. (2018) A System for an Accountable Data Analysis Process in R. R J 10:6-21
Sills, Aubrey M; Artavia, Joselyn M; DeRosa, Brian D et al. (2018) Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. Am J Primatol :e22927
Xu, Ming; Pirtskhalava, Tamar; Farr, Joshua N et al. (2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246-1256
Unnikrishnan, Archana; Hadad, Niran; Masser, Dustin R et al. (2018) Revisiting the genomic hypomethylation hypothesis of aging. Ann N Y Acad Sci 1418:69-79
Van Skike, Candice E; Jahrling, Jordan B; Olson, Angela B et al. (2018) Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol 314:H693-H703
Mao, Kai; Quipildor, Gabriela Farias; Tabrizian, Tahmineh et al. (2018) Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun 9:2394
Lee, Hak Joo; Feliers, Denis; Barnes, Jeffrey L et al. (2018) Hydrogen sulfide ameliorates aging-associated changes in the kidney. Geroscience 40:163-176
Kang, Donghoon; Kirienko, Daniel R; Webster, Phillip et al. (2018) Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. Virulence 9:804-817
Hook, Michael; Roy, Suheeta; Williams, Evan G et al. (2018) Genetic cartography of longevity in humans and mice: Current landscape and horizons. Biochim Biophys Acta Mol Basis Dis 1864:2718-2732

Showing the most recent 10 out of 231 publications