Abstract

This proposal describes the establishment of an Alzheimer's Disease Clinical Core unit at Northwestern University Medical School for the purpose of enhancing institutional initiatives related to the diagnosis, pathophysiology, molecular biology and treatment of Alzheimer's disease. To accomplish our goals, we will recruit and examine patients and nondemented control subjects and follow them at 6 month intervals. Every six months the neurological and neuropsychological examinations will be repeated and patients' caregivers will be interviewed in the context of """"""""therapeutic encounters."""""""" Information obtained from these evaluations will be entered into a database maintained on-site. The follow-up visits will provide continuity of care and will identify cognitive or behavioral changes that might require alternative management strategies. Commitments for brain autopsy will be solicited. Patients and control subjects will be contacted episodically by investigators of projects approved by the Northwestern ADCC Executive Committee and will sign separate informed consent forms for projects in which they agree to participate. A minority outreach program will actively target a population that is underserved with respect to up-to-date AD care and will recruit patients for participation in the Clinical Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013854-03
Application #
6267682
Study Section
Project Start
1998-07-15
Project End
1999-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Ramos, Eliana Marisa; Dokuru, Deepika Reddy; Van Berlo, Victoria et al. (2018) Genetic screen in a large series of patients with primary progressive aphasia. Alzheimers Dement :
Mesulam, M-Marsel; Rader, Benjamin M; Sridhar, Jaiashre et al. (2018) Word comprehension in temporal cortex and Wernicke area: A PPA perspective. Neurology :
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Hurley, Robert S; Mesulam, M-Marsel; Sridhar, Jaiashre et al. (2018) A nonverbal route to conceptual knowledge involving the right anterior temporal lobe. Neuropsychologia 117:92-101
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Bergeron, David; Gorno-Tempini, Maria L; Rabinovici, Gil D et al. (2018) Prevalence of amyloid-? pathology in distinct variants of primary progressive aphasia. Ann Neurol 84:729-740
Kim, Garam; Bolbolan, Kabriya; Gefen, Tamar et al. (2018) Atrophy and microglial distribution in primary progressive aphasia with transactive response DNA-binding protein-43 kDa. Ann Neurol 83:1096-1104
Pottier, Cyril; Zhou, Xiaolai; Perkerson 3rd, Ralph B et al. (2018) Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Lancet Neurol 17:548-558
Gefen, Tamar; Papastefan, Steven T; Rezvanian, Aras et al. (2018) Von Economo neurons of the anterior cingulate across the lifespan and in Alzheimer's disease. Cortex 99:69-77
Kim, Garam; Vahedi, Shahrooz; Gefen, Tamar et al. (2018) Asymmetric TDP pathology in primary progressive aphasia with right hemisphere language dominance. Neurology 90:e396-e403

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