Abstract

This proposal describes the establishment of an Alzheimer's Disease Clinical Core unit at Northwestern University Medical School for the purpose of enhancing institutional initiatives related to the diagnosis, pathophysiology, molecular biology and treatment of Alzheimer's disease. To accomplish our goals, we will recruit and examine patients and nondemented control subjects and follow them at 6 month intervals. Every six months the neurological and neuropsychological examinations will be repeated and patients' caregivers will be interviewed in the context of """"""""therapeutic encounters."""""""" Information obtained from these evaluations will be entered into a database maintained on-site. The follow-up visits will provide continuity of care and will identify cognitive or behavioral changes that might require alternative management strategies. Commitments for brain autopsy will be solicited. Patients and control subjects will be contacted episodically by investigators of projects approved by the Northwestern ADCC Executive Committee and will sign separate informed consent forms for projects in which they agree to participate. A minority outreach program will actively target a population that is underserved with respect to up-to-date AD care and will recruit patients for participation in the Clinical Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG013854-04S1
Application #
6098698
Study Section
Project Start
1999-08-01
Project End
2000-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124
Rogalski, Emily; Gefen, Tamar; Mao, Qinwen et al. (2018) Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases. Hippocampus :
Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307
Ramos, Eliana Marisa; Dokuru, Deepika Reddy; Van Berlo, Victoria et al. (2018) Genetic screen in a large series of patients with primary progressive aphasia. Alzheimers Dement :
Mesulam, M-Marsel; Rader, Benjamin M; Sridhar, Jaiashre et al. (2018) Word comprehension in temporal cortex and Wernicke area: A PPA perspective. Neurology :
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Hurley, Robert S; Mesulam, M-Marsel; Sridhar, Jaiashre et al. (2018) A nonverbal route to conceptual knowledge involving the right anterior temporal lobe. Neuropsychologia 117:92-101
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Bergeron, David; Gorno-Tempini, Maria L; Rabinovici, Gil D et al. (2018) Prevalence of amyloid-? pathology in distinct variants of primary progressive aphasia. Ann Neurol 84:729-740

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