This proposal seeks renewal of an Older Americans Independence Center at the Johns Hopkins Medical Institutions. The focus of this Center is to promote independence for frail older adults through the development of interventions to prevent or ameliorate frailty and the many serious, adverse outcomes that frail older adults are at risk for. To accomplish this, a multidisciplinary group of senior and junior investigators, in multiple departments and Programs at this institution, propose to continue and enhance, through this OAIC, 1. the Leadership Council that will stimulate, lead and sustain a University-wide interdisciplinary research program investigating frailty, its etiology and opportunities for treatment; 2. the infrastructure and methodologic development essential to creating the next generations of research on frailty in older adults; 3. support for the career development of outstanding junior faculty committed to research careers that will lead to treatments for frailty and its prevention; and 4. to cultivate and support pilot studies that will provide the basis for investigator-initiated and funded research towards interventions on frailty. The OAIC would provide the support critical to complement and harness the substantial strengths already at this institution into a unified and potent effort directed at developing interventions for frailty. It is designed to ensure multidisciplinary translation between basic, mechanistic and clinical/population-based research, and of each into development of treatments for frailty. This organized infrastructure and scientific leadership will serve as a source of advice and collaborations to investigators at our own institution and at other institutions in the area of research on frailty in aging. The OAIC will be administratively led by, and housed in, the Johns Hopkins Center on Aging and Health, with strong leadership and participation by all of the institutional programs committed to aging research; it will also seek to expand to incorporate leaders and investigators not previously involved in research on frailty but who have made a commitment to this work through the planning process for this proposal. This OAIC has strong institutional commitment, based on the priority at the Medical Institutions for the unification and strengthening of aging research and spotlighting its importance for the entire institution. Overall, it is designed to spearhead a new depth and intensity of research to improve outcomes and promote independence for frail, older adults. ? ? PROGRAM AS A WHOLE ? ? ?
| Wanigatunga, Amal A; Gresham, Gillian K; Kuo, Pei-Lun et al. (2018) Contrasting characteristics of daily physical activity in older adults by cancer history. Cancer 124:4692-4699 |
| Wilson, Katherine L (2018) Nuclear import pathway key to rescuing dominant progerin phenotypes. Sci Signal 11: |
| Schrack, Jennifer A; Leroux, Andrew; Fleg, Jerome L et al. (2018) Using Heart Rate and Accelerometry to Define Quantity and Intensity of Physical Activity in Older Adults. J Gerontol A Biol Sci Med Sci 73:668-675 |
| Gresham, Gillian; Schrack, Jennifer; Gresham, Louise M et al. (2018) Wearable activity monitors in oncology trials: Current use of an emerging technology. Contemp Clin Trials 64:13-21 |
| Nastasi, A J; McAdams-DeMarco, M A; Schrack, J et al. (2018) Pre-Kidney Transplant Lower Extremity Impairment and Post-Kidney Transplant Mortality. Am J Transplant 18:189-196 |
| McAdams-DeMarco, Mara A; Konel, Jonathan; Warsame, Fatima et al. (2018) Intradialytic Cognitive and Exercise Training May Preserve Cognitive Function. Kidney Int Rep 3:81-88 |
| Van Pilsum Rasmussen, Sarah; Konel, Jonathan; Warsame, Fatima et al. (2018) Engaging clinicians and patients to assess and improve frailty measurement in adults with end stage renal disease. BMC Nephrol 19:8 |
| Wanigatunga, Amal A; Simonsick, Eleanor M; Zipunnikov, Vadim et al. (2018) Perceived Fatigability and Objective Physical Activity in Mid- to Late-Life. J Gerontol A Biol Sci Med Sci 73:630-635 |
| Varadhan, Ravi; Walston, Jeremy D; Bandeen-Roche, Karen (2018) Can a Link Be Found Between Physical Resilience and Frailty in Older Adults by Studying Dynamical Systems? J Am Geriatr Soc 66:1455-1458 |
| Buta, B; Leder, D; Miller, R et al. (2018) The Use of Figurative Language to Describe Frailty in Older Adults. J Frailty Aging 7:127-133 |
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