Yale OAIC activities will focus on multifactorial geriatric health conditions-health conditions common among older persons that result from combinations of multiple factors, that may be prevented by multifactorial interventions, and that trigger multiple possible outcomes. Building on the foundation laid over previous periods of OAIC support, we will focus on identifying solutions to barriers impeding a more complete understanding of the etiology, prevention, treatment, and outcomes of multifactorial geriatric conditions. We propose a portfolio that includes: 1) investigations of traditional disease entities such as recurrent MI and pneumonia from the novel perspective of the geriatric syndrome model; 2) methodologic projects that take our epidemiologic and intervention studies to the next level of complexity by developing longitudinal methods for analyzing the effect of precipitating events on outcomes and for handling the common occurrence of bi-directionality (feed back loops) between risk factor or treatment and outcome and methods for determining the mechanisms of action of multifactorial intervention strategies; 3)novel applications of existing technologies, such as Geographic Information Systems, to evaluate the penetration, and effectiveness of real world implementation of multifactorial interventions; 4) the categorization, analysis, and dissemination of new and existing measures of multiple domains for use by investigators throughout all OAICs; 5) exploratory projects such as the development of a strategy for eliciting older persons' treatment goals when faced with multifactorial geriatric health conditions; and 6) capitalizing on unanticipated research opportunities and encouraging potential translational research as exemplified by a proposed pilot which examines alterations in oxidative stress responsiveness with human aging. This last project is particularly exciting because the paradigms guiding this work at the cellular level parallel those guiding Yale OAIC work at the human level, thus offering the promise of breakthrough discoveries concerning the etiology, prevention and treatment, of multifactorial geriatric health conditions. To support these, and other, projects the Yale OAIC will include the following Cores: 1) Biostatistics 2) Data Management/lnformatics 3) Field Core 4) research career development which will offer early career, transitional career, and affiliated faculty, Development awards.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
1P30AG021342-01
Application #
6549715
Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (M4))
Program Officer
Nayfield, Susan G
Project Start
2002-09-30
Project End
2003-07-31
Budget Start
2002-09-30
Budget End
2003-07-31
Support Year
1
Fiscal Year
2002
Total Cost
$1,603,277
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Ferrante, Lauren E; Murphy, Terrence E; Gahbauer, Evelyne A et al. (2018) Pre-Intensive Care Unit Cognitive Status, Subsequent Disability, and New Nursing Home Admission among Critically Ill Older Adults. Ann Am Thorac Soc 15:622-629
Knauert, Melissa P; Gilmore, Emily J; Murphy, Terrence E et al. (2018) Association between death and loss of stage N2 sleep features among critically Ill patients with delirium. J Crit Care 48:124-129
Brummel, Nathan E; Ferrante, Lauren E (2018) Integrating Geriatric Principles into Critical Care Medicine: The Time Is Now. Ann Am Thorac Soc 15:518-522
Monin, Joan K; Doyle, Margaret; Van Ness, Peter H et al. (2018) Longitudinal Associations Between Cognitive Functioning and Depressive Symptoms Among Older Adult Spouses in the Cardiovascular Health Study. Am J Geriatr Psychiatry 26:1036-1046
Wanigatunga, Amal A; Manini, Todd M; Cook, Delilah R et al. (2018) Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-Limited Older Adults. Front Aging Neurosci 10:341
Gill, Thomas M; Han, Ling; Gahbauer, Evelyne A et al. (2018) Prognostic Effect of Changes in Physical Function Over Prior Year on Subsequent Mortality and Long-Term Nursing Home Admission. J Am Geriatr Soc 66:1587-1591
Makris, Una E; Ferrante, Lauren E; Mody, Lona (2018) Leadership Lessons: Building and Nurturing a High-Performing Clinical Research Team. J Am Geriatr Soc 66:1258-1261
Snyder, Peter J; Bhasin, Shalender; Cunningham, Glenn R et al. (2018) Lessons From the Testosterone Trials. Endocr Rev 39:369-386
Kabiri, Mina; Brauer, Michelle; Shafrin, Jason et al. (2018) Long-Term Health and Economic Value of Improved Mobility among Older Adults in the United States. Value Health 21:792-798
Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487

Showing the most recent 10 out of 691 publications