Abstract

To identify genes and explore molecular pathways that regulate aging and susceptibility to age-related disorders in humans, well-characterized and genetically defined mice offer a choice model system. The Jackson Laboratory has a wealth of inbred and mutant strains of mice, expertise in mouse husbandry, and diversity of expertise in the biology of the mouse as it applies to aging. Establishing a Nathan Shock Center for Excellence in the Biology of Aging at The Jackson Laboratory will support an already significant level of age-related research here and, through a Research Development Core, attract both established investigators and new recruits to explore the relationship of their own research programs with questions pertinent to aging. Moreover, because The Jackson Laboratory is an international resource for information and unique strains of mice, the contribution of a Nathan Shock Center here will be leveraged nationally. Mice from individual Center members' research colonies will be aged in a dispersed Animal Core, that will open an enormous variety of genetic resources relevant to aging to other Center members and external scientists. The Phenome Core will offer an entirely new capability for predictive quantitative trait analysis to accelerate genetic analysis of the biology of aging, by characterizing parameters of aging for a set of commonly used, genetically diverse strains of mice and curating the data with detailed genomic sequence and mapping data in the publicly available Mouse Phenome Database. The Center will also support enhanced capabilities for invivo imaging, physiological measurements, and microscopy to evaluate phenotypes of aging through a Phenotyping Core. The Computing Core will provide support for statistical genetics analysis and workflow management tools. In sum, the Nathan Shock Center at The Jackson Laboratory will lead to enhanced resources for the international community and better understanding of the molecular mechanisms at work in aging and its associated disorders. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG025707-04S1
Application #
7678340
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (J1))
Program Officer
Sierra, Felipe
Project Start
2005-07-01
Project End
2010-06-30
Budget Start
2008-09-15
Budget End
2009-06-30
Support Year
4
Fiscal Year
2008
Total Cost
$174,000
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Linn, Sarah C; Mustonen, Allison M; Silva, Kathleen A et al. (2018) Nail abnormalities identified in an ageing study of 30 inbred mouse strains. Exp Dermatol :
Berndt, Annerose; Ackert-Bicknell, Cheryl; Silva, Kathleen A et al. (2016) Genetic determinants of fibro-osseous lesions in aged inbred mice. Exp Mol Pathol 100:92-100
Treuting, P M; Snyder, J M; Ikeno, Y et al. (2016) The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents. Vet Pathol 53:244-9
Bogue, Molly A; Peters, Luanne L; Paigen, Beverly et al. (2016) Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span. J Gerontol A Biol Sci Med Sci 71:170-7
Sundberg, J P; Berndt, A; Sundberg, B A et al. (2016) Approaches to Investigating Complex Genetic Traits in a Large-Scale Inbred Mouse Aging Study. Vet Pathol 53:456-67
Li, Qiaoli; Berndt, Annerose; Sundberg, Beth A et al. (2016) Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis. Mamm Genome 27:179-90
Aziz, Moammir H; Chen, Xundi; Zhang, Qi et al. (2015) Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo. Oncotarget 6:39714-24
Berndt, A; Sundberg, B A; Silva, K A et al. (2014) Phenotypic characterization of the KK/HlJ inbred mouse strain. Vet Pathol 51:846-57
Strong, Randy; Miller, Richard A; Astle, Clinton M et al. (2013) Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 68:6-16
Schofield, Paul N; Vogel, Peter; Gkoutos, Georgios V et al. (2012) Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice. Dis Model Mech 5:19-25

Showing the most recent 10 out of 39 publications