? Comparative Data Analytics Core The Comparative Data Analytics Core (Analytics Core) will provide not only high-level customized statistical support for basic science investigators studying aging and energetics in diverse model organisms at UAB, but also a venue for development of de novo methods specially for such research and a platform for the dissemination of such methods to the aging research community at large. The core leadership comprises statistical scientists with decades of combined history of studying the interface of aging, energetics and body composition. They bring not only their statistical expertise, but their experience with and zeal for the science of comparative studies at the interface of aging and energetics. The need for specialized statistical expertise and support in aging research is clear. Statistical analyses of aging research data provide many challenges. Aging research involves longitudinal analyses and modeling the dependency of multiple observations taken over time, and accommodating the missing data that commonly occurs with longitudinal studies. Left, right, and interval censoring add further complexities with time-to-event (e.g., survival) outcomes. Statistical approaches in comparative biology face challenges such as phylogenetic dependence among model residuals that complicate inference. Non-statistician researchers benefit from the support and involvement of statistical scientists who are deeply involved in the subject matter, who can tailor methods to the situation at hand, who work with the biologists from the beginning as an engaged part of the research team, who can discuss the methods with the biologists and explain the statistical procedures and who can develop new statistical methods for specific needs. To that end, the Analytics Core offers the following specific aims:
Specific Aims 1 /2: To provide statistical support for 1) UAB investigators and 2) non-UAB investigators studying the comparative energetics of aging, including traditional, specialized, and bespoke methods.
Specific Aim 3 : To conduct high-level statistical investigations of secondary data to answer questions about the comparative energetics of aging.
Specific Aim 4 : To develop and evaluate statistical methods needed in the field of the comparative energetics of aging.
Specific Aim 5 : To provide reproducibility, verification, and transparency support for aging researchers. An investment in this core will achieve dividends by catalyzing more informative and rigorous research on aging within the UAB NSC and for the community of aging researchers at large. 1 of 1
| Xu, Ming; Pirtskhalava, Tamar; Farr, Joshua N et al. (2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246-1256 |
| Chusyd, Daniella E; Brown, Janine L; Hambly, Catherine et al. (2018) Adiposity and Reproductive Cycling Status in Zoo African Elephants. Obesity (Silver Spring) 26:103-110 |
| Mao, Kai; Quipildor, Gabriela Farias; Tabrizian, Tahmineh et al. (2018) Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun 9:2394 |
| Brown, Andrew W; Kaiser, Kathryn A; Allison, David B (2018) Issues with data and analyses: Errors, underlying themes, and potential solutions. Proc Natl Acad Sci U S A 115:2563-2570 |
| Fischer, Kathleen E; Riddle, Nicole C (2018) Sex Differences in Aging: Genomic Instability. J Gerontol A Biol Sci Med Sci 73:166-174 |
| Rangarajan, Sunad; Bone, Nathaniel B; Zmijewska, Anna A et al. (2018) Metformin reverses established lung fibrosis in a bleomycin model. Nat Med 24:1121-1127 |
| Gibbs, Victoria K; Schwartz, Tonia S; Johnson, Maria S et al. (2018) No Significant Effect of Maternal Perception of the Food Environment on Reproductive Success or Pup Outcomes in C57BL/6J Mice. Obesity (Silver Spring) 26:723-729 |
| Zhang, Jianhua; Culp, Matilda Lillian; Craver, Jason G et al. (2018) Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease. J Neurochem 144:691-709 |
| Gardinassi, Luiz G; Arévalo-Herrera, Myriam; Herrera, Sócrates et al. (2018) Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling. Redox Biol 17:158-170 |
| Austad, Steven N (2018) The Comparative Biology of Mitochondrial Function and the Rate of Aging. Integr Comp Biol 58:559-566 |
Showing the most recent 10 out of 34 publications
