The Research Development Core of the Oklahoma Nathan Shock Center is an innovative departure from the traditional structure of similar cores in Nathan Shock Centers. Research Development Cores generally support a limited number of junior faculty members (2-4) within the academic institution using a fixed monetary pilot award (e.g. $25,000-50,000). The Development Core of the Oklahoma Nathan Shock Center is designed to provide unprecedented service to the scientific community at large. Our goal is to increase the number of investigators across the country that conduct research in aging by providing funded access to a series of relevant and specialized technologies not often present within an individual laboratory and educational, mentoring, and collaborative resources that aid in the development of and/or transition to an independent career in research in the biology of aging and age- related diseases (Geroscience). Three goals are proposed for the Research Development Core:
Aim 1. Support pilot/feasibility projects for young investigators interested in conducting research in the biology of aging; a. investigators outside of Oklahoma will be supported through the Nathan Shock Center, and b. investigators inside of Oklahoma will be supported through local funding sources.
Aim 2. Provide collaborative opportunities for mid-level and senior investigators with interests in Geroscience e.g. investigators with experience in diseases associated with aging but with limited experience in conducting aging research.
Aim 3. a. Disseminate novel technologies to the aging community and train researchers in best practices, and b. Evaluate strengths and weaknesses of the Research Development Core. The goals of the Development Core are highly leveraged using resources available to us from the Reynolds Oklahoma Center on Aging, OUHSC/OMRF and local funding agencies. Based on information provided through our website, at national meetings and direct contact with individuals regarding grant awards (NIA/AFAR), we expect that the unique services of the development core will be widely used by investigators across the country and will advance the field of aging and Geroscience research. We expect that this novel program will be transformative for advancing the careers of young scientists and integrating mid-level and senior scientists to Geroscience research.

Public Health Relevance

The Research Development Core of the Oklahoma Shock Center is a radical departure from the typical Research Development Cores found in all Shock Centers. True to our goal to reach out to the aging community, the Research Development Core is focused entirely on serving junior investigators around the country entering the field of aging and established investigators interested in transitioning their research to the interaction of aging and age-related disease, i.e., Geroscience. The Research Development Core is designed to be a unique catalyst to aging research and is based on a strategy of interaction and collaboration between colleagues.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
7P30AG050911-02
Application #
9110091
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Type
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
Li, Xiaomeng; Oh, Sangphil; Song, Hoogeun et al. (2018) A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer. Oncol Lett 16:6652-6662
Imperio, Caesar G; McFalls, Ashley J; Hadad, Niran et al. (2018) Exposure to environmental enrichment attenuates addiction-like behavior and alters molecular effects of heroin self-administration in rats. Neuropharmacology 139:26-40
Gardner, Andrew W; Montgomery, Polly S; Zhao, Yan D et al. (2018) Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease. Angiology 69:416-423
Unnikrishnan, Archana; Hadad, Niran; Masser, Dustin R et al. (2018) Revisiting the genomic hypomethylation hypothesis of aging. Ann N Y Acad Sci 1418:69-79
Masser, Dustin R; Hadad, Niran; Porter, Hunter et al. (2018) Analysis of DNA modifications in aging research. Geroscience 40:11-29
Wren, Jonathan D (2018) Algorithmically outsourcing the detection of statistical errors and other problems. EMBO J 37:
Min, Kyung-Won; Zealy, Richard W; Davila, Sylvia et al. (2018) Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability. Aging Cell 17:e12753
Schafer, Christopher; Young, Zachary T; Makarewich, Catherine A et al. (2018) Coenzyme A-mediated degradation of pyruvate dehydrogenase kinase 4 promotes cardiac metabolic flexibility after high-fat feeding in mice. J Biol Chem 293:6915-6924
Van Skike, Candice E; Jahrling, Jordan B; Olson, Angela B et al. (2018) Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol 314:H693-H703
Logan, Sreemathi; Pharaoh, Gavin A; Marlin, M Caleb et al. (2018) Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-? uptake in astrocytes. Mol Metab 9:141-155

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