Abstract

Investigators in the Medical and Veterinary Schools and Primate Center at University of California, Davis (UCD) have forced a Cooperative Group for research on AIDS in human and AIDS-like disease in animals. This multidisciplinary group now consists of 15 Principal Investigators and a funding base of approximately 4M/year primarily from 37 grants from NIH and the State of California. The intention of the Group is to become in about 2 years an independent, organized Center for AIDS Research and Vaccinology within the University of California system. The overall research goals of the Group are to understand the natural history and pathogenesis of simian, feline and human AIDS and to use these models for development of effective retroviral therapies and vaccines. In the near future we plan to continue research on SRV, SIV and FILV induced immunosuppression, to integrate our basic and clinical HIV research efforts, to continue our SIV and HIV vaccine efforts and to develop new programs in SIV cellular immunology and HIV/SIV transgenic mice. This CFAR application consists of an Administration Unit three core components, A) Clinical Virology, B) Primate Center, C) Molecular Virology and two discretionary/developmental areas, 1) HIV/SIV transgenic mice and 2) SIV Cellular Immunology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
3P30AI027732-05S1
Application #
2064050
Study Section
Special Emphasis Panel (SRC (41))
Project Start
1988-09-30
Project End
1994-08-31
Budget Start
1992-09-01
Budget End
1994-08-31
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Pathology
Type
Schools of Medicine
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Yamanaka, M K; Yilma, T (1998) Altered plaque formation by recombinant vaccinia virus expressing simian immunodeficiency virus Nef. J Virol 72:5291-5
Giavedoni, L D; Yilma, T (1996) Construction and characterization of replication-competent simian immunodeficiency virus vectors that express gamma interferon. J Virol 70:2247-51
Gardner, M; Rosenthal, A; Jennings, M et al. (1995) Passive immunization of rhesus macaques against SIV infection and disease. AIDS Res Hum Retroviruses 11:843-54
Luciw, P A; Pratt-Lowe, E; Shaw, K E et al. (1995) Persistent infection of rhesus macaques with T-cell-line-tropic and macrophage-tropic clones of simian/human immunodeficiency viruses (SHIV). Proc Natl Acad Sci U S A 92:7490-4
Gardner, M B; Rosenthal, A; Jennings, M et al. (1994) Passive immunization of macaques against SIV infection. J Med Primatol 23:164-74
Ahmad, S; Lohman, B; Marthas, M et al. (1994) Reduced virus load in rhesus macaques immunized with recombinant gp160 and challenged with simian immunodeficiency virus. AIDS Res Hum Retroviruses 10:195-204
Herchenroder, O; Renne, R; Loncar, D et al. (1994) Isolation, cloning, and sequencing of simian foamy viruses from chimpanzees (SFVcpz): high homology to human foamy virus (HFV). Virology 201:187-99
Anderson, D E; Malley, A; Benjamini, E et al. (1994) Hypervariable epitope constructs as a means of accounting for epitope variability. Vaccine 12:736-40
Renne, R; Mergia, A; Renshaw-Gegg, L W et al. (1993) Regulatory elements in the long terminal repeat (LTR) of simian foamy virus type 3 (SFV-3). Virology 192:365-9
Torres, J V; Malley, A; Banapour, B et al. (1993) An epitope on the surface envelope glycoprotein (gp130) of simian immunodeficiency virus (SIVmac) involved in viral neutralization and T cell activation. AIDS Res Hum Retroviruses 9:423-30

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