The AECOM CFAR intends to continue to utilize developmental funds to recruit two investigators new to AIDS research, who have not previously received individual RO1 equivalent support in this field. In year 6 the first priority will be given to a molecular or cellular immunologist with expertise in vaccine development. Funding will be provided for a maximum of two years. Mechanisms of recruitment will be modelled after comparable efforts already in place in the CFAR, and the AECOM Cancer Research Center and Liver Research Center. The position will also be advertised in scientific journals and, to facilitate recruitment of minority candidates, letters will be written to graduate schools with a major focus on minority programs. Applications will be reviewed by Dr. Lilly and submitted for approval of the Steering Committee and the IAC. Potential new investigators from within the institution and from outside will be evaluated and selected based on recommendations of the Steering Committee, Internal (IAC) and External Advisory (IAC) Committee. We will continue yearly support for one feasibility study by an AECOM investigator, preparatory to the development of an application for prior reviewed support. Finally, funds will be set aside for two evolving research opportunities among AECOM investigators. This support will be limited to six months to address arising critical ideas that demand rapid solution. Encouragement will be given to applications entailing basic and clinical research collaboration.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI027741-08
Application #
5205349
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Rubinstein, Arye (2005) Preclinical studies of alkylureas as anti-HIV-1 contraceptive. Curr Pharm Des 11:3769-78
Lenz, J; Su, M; Mizrachi, Y et al. (2001) V3 variation in HIV-seropositive patients receiving a V3- targeted vaccine. AIDS 15:577-81
Browning Paul, J; Wang, E J; Pettoello-Mantovani, M et al. (2000) Mice transgenic for monocyte-tropic HIV type 1 produce infectious virus and display plasma viremia: a new in vivo system for studying the postintegration phase of HIV replication. AIDS Res Hum Retroviruses 16:481-92
Rubinstein, A; Mizrachi, Y; Bernstein, L et al. (2000) Progressive specific immune attrition after primary, secondary and tertiary immunizations with bacteriophage phi X174 in asymptomatic HIV-1 infected patients. AIDS 14:F55-62
Yurasov, S V; Pettoello-Mantovani, M; Raker, C A et al. (1999) HIV type 1 infection of human fetal bone marrow cells induces apoptotic changes in hematopoietic precursor cells and suppresses their in vitro differentiation and capacity to engraft SCID mice. AIDS Res Hum Retroviruses 15:1639-52
Rubinstein, A; Mizrachi, Y; Pettoello-Mantovani, M et al. (1999) Immunologic responses of HIV-1-infected study subjects to immunization with a mixture of peptide protein derivative-V3 loop peptide conjugates. J Acquir Immune Defic Syndr 22:467-76
Pettoello-Mantovani, M; Kollmann, T R; Katopodis, N F et al. (1998) thy/liv-SCID-hu mice: a system for investigating the in vivo effects of multidrug therapy on plasma viremia and human immunodeficiency virus replication in lymphoid tissues. J Infect Dis 177:337-46
Landor, M; Rubinstein, A; Kim, A et al. (1998) Receptor-mediated maternofetal transfer of immunoglobulins. Inhibition of transport of anti-HIV-1 immunoglobulin by generic immunoglobulins in the in vitro perfused placenta. Int Arch Allergy Immunol 115:203-9
Browning, J; Horner, J W; Pettoello-Mantovani, M et al. (1997) Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection. Proc Natl Acad Sci U S A 94:14637-41
Harish, Z; Rubinstein, A; Golodner, M et al. (1997) Suppression of HIV-1 replication by propolis and its immunoregulatory effect. Drugs Exp Clin Res 23:89-96

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