The Center for AIDS Research at NYU Medical Center comprises seventy clinical and basic science investigators performing research in three contiguous institutions in lower Manhattan and one across the river in Newark. These scientists are affiliated with the NYU School of medicine, although their laboratories and research clinics are located at the Manhattan VA Hospital, Bellevue Hospital, the New York Public Health Research Institute, as well as the School of Medicine buildings, including Tisch Hospital and Skirball Institute. Many important contributions to our understanding of the virology, immunology, epidemiology, and the infections and neoplastic complications of this disease have been made by NYU investigators since they identified their first patient in 1980. NYU clinicians are caring for over 4,000 HIV-infected individuals, and our clinical research efforts attract additional patients from the several thousands of HIV + subjects throughout the metropolitan region. This research is currently supported by over $25 M in AIDS-related funding, which includes over $15 M in yearly funding from the NIH. The CFAR supports this productive program of research and increases its efficiency by four shared core facilities, and developmental funds to support young investigators and new research opportunities. The CFAR also brings together investigators with similar interests into several research programs to facilitate innovation and collaboration. CORE A: Administrative Core (Valentine, F) DESCRIPTION (provided by applicant): The Administration Unit (Core) provides overall leadership and administrative management to the CFAR. The Administration is directed by Fred Valentine, M.D., with the support of two Associate Directors, Dan Littman, M.D., Ph.D. for Basic Science and William Borkowsky, M.D., for Clinical Research. The responsibilities of the Administration fall into two categories: 1) Providing proactive leadership in expanding HIV-related collaborative and translational research, 2) Ensuring that the multiple elements of the Center function together as a Center, that the whole is in fact greater than the sum of its parts. The senior leadership establishes the goals of the Center and, through the Center's programmatic and core structure, creates the optimal environment for interaction, growth and support of HIV research. The Director also works with the Administrators, Ms. Andrea Barrett and Irini Albanti, to ensure the smooth operation of the Center's chief administrative functions. These include: policies to guide the CFAR operations;budgetary stewardship;internal and external communication systems;planning and evaluation of CFAR activities, helping investigators and working with the development office on fund raising for CFAR. The Administrative Core functions primarily to provide the administrative support systems and management tools needed to maintain the CFAR's activities. This Core is responsible for fostering and tracking the scientific productivity and progress of its members. The Core also organizes and expands our outreach and international scientific and educational activities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI027742-20
Application #
7671469
Study Section
Special Emphasis Panel (ZAI1-LW-A (J1))
Program Officer
Namkung, Ann S
Project Start
1997-07-01
Project End
2012-06-30
Budget Start
2009-07-01
Budget End
2012-06-30
Support Year
20
Fiscal Year
2009
Total Cost
$1,977,464
Indirect Cost
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Gornalusse, German G; Mummidi, Srinivas; Gaitan, Alvaro A et al. (2015) Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor. Proc Natl Acad Sci U S A 112:E4762-71
Miller, Elizabeth A; Gopal, Ramya; Valdes, Vanessa et al. (2015) Soluble CD40 ligand contributes to dendritic cell-mediated T-cell dysfunction in HIV-1 infection. AIDS 29:1287-96
Weiden, Michael D; Hoshino, Satomi; Levy, David N et al. (2014) Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HIV-1 replication in human alveolar macrophages. PLoS One 9:e108476
Ryndak, Michelle B; Singh, Krishna K; Peng, Zhengyu et al. (2014) Transcriptional profiling of Mycobacterium tuberculosis replicating ex vivo in blood from HIV- and HIV+ subjects. PLoS One 9:e94939
Phelan, Joan A; Abrams, William R; Norman, Robert G et al. (2014) Design aspects of a case-control clinical investigation of the effect of HIV on oral and gastrointestinal soluble innate factors and microbes. PLoS One 9:e112901
Sivapalasingam, Sumathi; Mendillo, Megan; Ahmed, Aabid et al. (2014) The importance of caregivers in the outcome of pediatric HIV management, Mombasa, Kenya. AIDS Care 26:425-33
Weiser, Keren; Barton, Meredith; Gershoony, Dafna et al. (2013) HIV's Nef interacts with ?-catenin of the Wnt signaling pathway in HEK293 cells. PLoS One 8:e77865
O'Brien, Meagan; Montenont, Emilie; Hu, Liang et al. (2013) Aspirin attenuates platelet activation and immune activation in HIV-1-infected subjects on antiretroviral therapy: a pilot study. J Acquir Immune Defic Syndr 63:280-8
Rich, Josiah D; DiClemente, Ralph; Levy, Judith et al. (2013) Correctional facilities as partners in reducing HIV disparities. J Acquir Immune Defic Syndr 63 Suppl 1:S49-53
Alvarez, Yelina; Tuen, Michael; NĂ das, Arthur et al. (2012) In vitro restoration of Th17 response during HIV infection with an antiretroviral drug and Th17 differentiation cytokines. AIDS Res Hum Retroviruses 28:823-34

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