The UW Clinical Research Core was initiated in 1988 to support pilot clinical trials proposed by UW junior faculty members of senior faculty initiating new research in the area of HIV. Since its inception it has supported 17 clinical trials enrolling over 900 patients. Over 20 publications have ensued from this work, and the pilot data have led to 8 funded research applications. In this funding period we propose to expand the UW CFAR to include both a Seattle based and Internationally based CRC. The Seattle based program will continue to emphasize short term limited support of interdisciplinary studies that are directed at the epidemiology and biology of HIV acquisition/transmission. One current effort is a detailed study of the immunologic and virologic aspects of acute subclinical primary HIV-1 infection. Within last few years, the UW has established several cohort studies in International sites that are directed at the transmission/acquisition of HIV infection. The International CRC will directed at improving the interdisciplinary aspects of these studies. CFAR International CRC resources will be devoted at supporting the acquisition, storage and shipment of specimens from these cohort studies of collaborating laboratory based investigators at the UW; especially those involved in retrovirology and immunology based research. To date, the request for CFAR CRC resources have far exceeded available resources. An Internal Scientific Review Committee consisting of the CFAR CRC resources have far exceeded available resources. An Internal Scientific Review Committee consisting of the CFAR Director, Associated Directors and the Internal Review Committee listed below will review concept sheets from CFAR investigators and prioritize the utilization and duration of CFAR resources for approval projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI027757-14
Application #
6446091
Study Section
Project Start
2001-03-01
Project End
2002-02-28
Budget Start
Budget End
Support Year
14
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Wagner, Anjuli D; O?Malley, Gabrielle; Firdawsi, Olivia et al. (2018) Brief Report: Disclosure, Consent, Opportunity Costs, and Inaccurate Risk Assessment Deter Pediatric HIV Testing: A Mixed-Methods Study. J Acquir Immune Defic Syndr 77:393-399
Merlin, Jessica S; Long, Dustin; Becker, William C et al. (2018) Brief Report: The Association of Chronic Pain and Long-Term Opioid Therapy With HIV Treatment Outcomes. J Acquir Immune Defic Syndr 79:77-82
LaCourse, Sylvia M; Cranmer, Lisa M; Njuguna, Irene N et al. (2018) Urine Tuberculosis Lipoarabinomannan Predicts Mortality in Hospitalized Human Immunodeficiency Virus-Infected Children. Clin Infect Dis 66:1798-1801
Golovaty, Ilya; Sharma, Monisha; Van Heerden, Alastair et al. (2018) Cost of Integrating Noncommunicable Disease Screening Into Home-Based HIV Testing and Counseling in South Africa. J Acquir Immune Defic Syndr 78:522-526
Torres, Thiago S; Harrison, Linda J; La Rosa, Alberto M et al. (2018) Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women. AIDS 32:583-593
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
Patel, Rena C; Bukusi, Elizabeth A; Baeten, Jared M (2018) Current and future contraceptive options for women living with HIV. Expert Opin Pharmacother 19:1-12
Ross, Jennifer M; Ying, Roger; Celum, Connie L et al. (2018) Modeling HIV disease progression and transmission at population-level: The potential impact of modifying disease progression in HIV treatment programs. Epidemics 23:34-41
Wagner, Anjuli D; Shah, Seema K; Njuguna, Irene N et al. (2018) Financial Incentives to Motivate Pediatric HIV Testing-Assessing the Potential for Coercion, Inducement, and Voluntariness. J Acquir Immune Defic Syndr 78:e15-e18
Stekler, Joanne D; Milne, Ross; Payant, Rachel et al. (2018) Transmission of HIV-1 drug resistance mutations within partner-pairs: A cross-sectional study of a primary HIV infection cohort. PLoS Med 15:e1002537

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