Clinical Retrovirology

Coombs, Robert W.

Abstract

CORE F - University of Washington CFAR Clinical Retrovirology Laboratory Core. Director-Robert W Coombs, M.D., Ph.D., Professor, Departments of Laboratory Medicine &Medicine;Co-Director, Tuofu Zhu, M.D., Ph.D., Associate Professor, Department of Laboratory Medicine. SPECIFIC PURPOSE AND KEY SCIENTIFIC PROJECTS SUPPORTED. The specific purpose of the Clinical Retrovirology Laboratory Core is to facilitate the translational and interdisciplinary CFAR research agenda of prevention, pathogenesis and treatment of HIV infection by providing and developing HIV virology laboratory support and services for CFAR investigators. This purpose will be accomplished by providing virological markers of disease progression and regression and maintenance of a CFAR specimen repository in conjunction with the Clinical Research Core. In addition, to serological diagnosis of HIV, viral isolation, RNA and DMA quantification, and detection procedures for HIV shedding from mucosal surfaces are also available and a special expertise of Core F. A diverse virological laboratory base is important for elucidating HIV pathogenesis, vaccines and treatment strategies, which are major themes of the UW CFAR proposal. The key scientific projects in progress and currently supported by the Clinical Retrovirology Core Laboratory include: Continued laboratory support of the Adult and Pediatric AIDS Clinical Trials Networks (AI-27664;Al- 32910), HIV Vaccine Trials Network (AI-26503) and Primary Infection Program (AI-57005);HIV-1 shedding, transmission and tropism (AI-38518;R21 pending);Evolution of HIV-1 variants in semen and blood (Al- 32885, AI-35539);Virological and host determinants of HIV-1 shedding in semen (DK-49477);Effect of female genital tract infection on HIV-1 shedding and evolution (HD40540);Effect of mucosal inflammation and HSV on HIV shedding (AI-4798;CFAR/CIPRA programs);Lymphoctye adhesion and HIV activation in the lung (RO1-HL083481);Mycobacterium infection and host defense (K08-HL03577);Pathogenesis of HIV env and vaccines (AI-47086;AI-065328;HD-38653);and HIV CNS infection and dementia (R21-MH63647).

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Center Core Grants (P30)
• Project #: 5P30AI027757-23
• Application #: 8080966
• Study Section: Special Emphasis Panel (ZAI1)
• Budget Start: 2010-06-01
• Budget End: 2011-05-31
• Support Year: 23
• Fiscal Year: 2010
• Total Cost: $173,654

Institution

• Name: University of Washington
• DUNS #: 605799469
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98195

Publications

Thomson, Kerry A; Dhanireddy, Shireesha; Andrasik, Michele et al. (2018) Fertility desires and preferences for safer conception strategies among people receiving care for HIV at a publicly-funded clinic in Seattle, WA. AIDS Care 30:121-129

Lohman-Payne, Barbara; Gabriel, Benjamin; Park, Sangshin et al. (2018) HIV-exposed uninfected infants: elevated cord blood Interleukin 8 (IL-8) is significantly associated with maternal HIV infection and systemic IL-8 in a Kenyan cohort. Clin Transl Med 7:26

McGrath, Christine J; Singa, Benson; Langat, Agnes et al. (2018) Non-disclosure to male partners and incomplete PMTCT regimens associated with higher risk of mother-to-child HIV transmission: a national survey in Kenya. AIDS Care 30:765-773

Njuguna, Irene N; Wagner, Anjuli D; Omondi, Vincent O et al. (2018) Financial Incentives for Pediatric HIV Testing in Kenya. Pediatr Infect Dis J 37:1142-1144

Stone, Mars; Bainbridge, John; Sanchez, Ana M et al. (2018) Comparison of Detection Limits of Fourth- and Fifth-Generation Combination HIV Antigen-Antibody, p24 Antigen, and Viral Load Assays on Diverse HIV Isolates. J Clin Microbiol 56:

Ronen, Keshet; Unger, Jennifer A; Drake, Alison L et al. (2018) SMS messaging to improve ART adherence: perspectives of pregnant HIV-infected women in Kenya on HIV-related message content. AIDS Care 30:500-505

Roberts, Sarah T; Flaherty, Brian P; Deya, Ruth et al. (2018) Patterns of Gender-Based Violence and Associations with Mental Health and HIV Risk Behavior Among Female Sex Workers in Mombasa, Kenya: A Latent Class Analysis. AIDS Behav 22:3273-3286

Duarte, Horacio A; Beck, Ingrid A; Levine, Molly et al. (2018) Implementation of a point mutation assay for HIV drug resistance testing in Kenya. AIDS 32:2301-2308

Herbeck, Joshua T; Peebles, Kathryn; Edlefsen, Paul T et al. (2018) HIV population-level adaptation can rapidly diminish the impact of a partially effective vaccine. Vaccine 36:514-520

Shapiro, Adrienne E; van Heerden, Alastair; Schaafsma, Torin T et al. (2018) Completion of the tuberculosis care cascade in a community-based HIV linkage-to-care study in South Africa and Uganda. J Int AIDS Soc 21: