Cancer is increasingly recognized as an important complication of HIV infection, with -10% of HIV-infected persons expected to develop cancer at some point in their lifetime. For many HIV-associated malignancies (HIVAM), few good strategies for prevention or treatment exist. Seattle has developed an extraordinary community of researchers in both cancer and HIV, and over the last five years the AIDS-Associated Infections and Malignancies (AAlMs) Scientific Working Group has been highly successful in bringing together these research communities to address HIVAM. We now propose to expand the activities of the AAlMs group to become a Core in the UW/FHCRC CFAR, with three Specific Aims: 1) Enable studies of HIVAM through the development and deployment of assays for the molecular detection and quantification of viral oncogens;2) Facilitate the diagnosis of HIVAM, as well as detailed studies of HIVAM pathogenesis, in CFAR-affiliated HIV cohorts through the provision of a suite of molecular and immunohistochemical tumor assays;3) Disseminate data instruments to accurately identify and characterize cancer endpoints among HIV-infected persons participating in CFAR-affiliated research studies. To achieve these goals, we have assembled a group of international experts from the Fred Hutchinson Cancer Research Center and the University of Washington to serve on the Core's Steering Committee, leveraged the highly successful Molecular Diagnostics Laboratories in Seattle and Uganda, expanded core pathology diagnostic services offered by the Hutchinson Center and the Seattle Cancer Care Alliance, and utilized the expertise in data collection of the Statistical Center for HIV/AIDS Research &Prevention.

Public Health Relevance

Cancer is a common complication of HIV infection, and better strategies for cancer prevention and treatment are needed. The AIDS-Associated Infections and Malignancies Core will facilitate innovative research in cancer among persons with HIV infection by offering investigators molecular, diagnostic and data tools to increase the scope, quantity and quality of cancer research in cohorts of HIV-infected individuals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI027757-27
Application #
8683043
Study Section
Special Emphasis Panel (ZAI1-UKS-A)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
27
Fiscal Year
2014
Total Cost
$410,818
Indirect Cost
$102,169
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Young, J; Smith, C; Teira, R et al. (2018) Antiretroviral pill count and clinical outcomes in treatment-naïve patients with HIV infection. HIV Med 19:132-142
Olwit, Connie; Mugaba, Maureen; Osingada, Charles Peter et al. (2018) Existence, triggers, and coping with chronic sorrow: a qualitative study of caretakers of children with sickle cell disease in a National Referral Hospital in Kampala, Uganda. BMC Psychol 6:50
Torres, Thiago S; Harrison, Linda J; La Rosa, Alberto M et al. (2018) Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings. AIDS Care 30:954-962
Heffron, Renee; Mugo, Nelly; Hong, Ting et al. (2018) Pregnancy outcomes and infant growth among babies with in-utero exposure to tenofovir-based preexposure prophylaxis for HIV prevention. AIDS 32:1707-1713
Pyra, Maria; Brown, Elizabeth R; Haberer, Jessica E et al. (2018) Patterns of Oral PrEP Adherence and HIV Risk Among Eastern African Women in HIV Serodiscordant Partnerships. AIDS Behav :
Jiang, Wei; Luo, Zhenwu; Martin, Lisa et al. (2018) Drug Use is Associated with Anti-CD4 IgG-mediated CD4+ T Cell Death and Poor CD4+ T Cell Recovery in Viral-suppressive HIV-infected Individuals Under Antiretroviral Therapy. Curr HIV Res 16:143-150
Edwards, Jessie K; Cole, Stephen R; Moore, Richard D et al. (2018) Sensitivity Analyses for Misclassification of Cause of Death in the Parametric G-Formula. Am J Epidemiol :
LaCourse, Sylvia M; Cranmer, Lisa M; Bekker, Adrie et al. (2018) Symptom screening for active tuberculosis in pregnant women living with HIV. Cochrane Database Syst Rev 2018:
Merlin, Jessica S; Long, Dustin; Becker, William C et al. (2018) Brief Report: The Association of Chronic Pain and Long-Term Opioid Therapy With HIV Treatment Outcomes. J Acquir Immune Defic Syndr 79:77-82
Wagner, Anjuli D; O?Malley, Gabrielle; Firdawsi, Olivia et al. (2018) Brief Report: Disclosure, Consent, Opportunity Costs, and Inaccurate Risk Assessment Deter Pediatric HIV Testing: A Mixed-Methods Study. J Acquir Immune Defic Syndr 77:393-399

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