The primary aim of the UCSF-GIVI CFAR is to nurture and sustain innovative multidisciplinary HIV research at the intersections of the basic, clinical, behavioral and epidemiologic scientific disciplines. All decisions made within the Center are carefully measured against this research goal. The Center?s leadership reflects the scientific and geographic diversity of HIV research in San Francisco, and is committed to proactive rather than reactive management, which is greatly facilitated by regular weekly meetings and quarterly off-site strategic planning retreats. To catalyze multidisciplinary research, the Center has established seven scientific cores (Clinical, Behavioral Science and Epidemiology, Immunology, Virology, Pathology, Specimen Banking, and Pharmacology). Core Directors are charged with actively encouraging new investigators to join the multidisciplinary HIV research effort by taking advantage of the cutting-edge technologies and assays available within the core laboratories. Success of the scientific cores is measured by the quality of the multidisciplinary science they help to stimulate and by the publications and successful grants to which they contribute. Center activities are coordinated by an Administrative Core that maintains an electronic network to connect and inform all CFAR members, organizes scientific seminars and symposia, and implements financial systems that permit close monitoring of all CFAR funds, thereby ensuring that CFAR resources are used to maximum benefit. Such financial oversight has allowed the CFAR leadership, on occasion, to reallocate monies to support high priority research initiatives identified through strategic planning. The Developmental Core provides funding for pilot projects of young investigators and actively mentors them to help ensure their steady growth and development as young scientists. Developmental funds are also used to support strategic initiatives within the Center, when possible. The success of the UCSF-GIVI CFAR is evident in the scientific accomplishments of its investigators, its ability to galvanize fundamentally new science through its focus on innovative multidisciplinary HIV research, and the significant institutional support it receives from UCSF, the San Francisco Veterans Affairs Medical Center and The J. David Gladstone Institutes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI027763-11
Application #
6464895
Study Section
Special Emphasis Panel (ZAI1-HSD-A (J1))
Program Officer
Young, Janet M
Project Start
2002-07-15
Project End
2007-06-30
Budget Start
2002-07-15
Budget End
2003-06-30
Support Year
11
Fiscal Year
2002
Total Cost
$2,456,480
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Streubel, Gundula; Watson, Ariane; Jammula, Sri Ganesh et al. (2018) The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells. Mol Cell 70:371-379.e5
Dunkley, Emma; Ashaba, Scholastic; Burns, Bridget et al. (2018) ""I beg you…breastfeed the baby, things changed"": infant feeding experiences among Ugandan mothers living with HIV in the context of evolving guidelines to prevent postnatal transmission. BMC Public Health 18:188
Cary, Daniele C; Peterlin, B Matija (2018) Natural Products and HIV/AIDS. AIDS Res Hum Retroviruses 34:31-38
Carrico, Adam W; G?mez, Walter; Jain, Jennifer et al. (2018) Randomized controlled trial of a positive affect intervention for methamphetamine users. Drug Alcohol Depend 192:8-15
Holmes, Charles B; Sikazwe, Izukanji; Sikombe, Kombatende et al. (2018) Estimated mortality on HIV treatment among active patients and patients lost to follow-up in 4 provinces of Zambia: Findings from a multistage sampling-based survey. PLoS Med 15:e1002489
Buggert, Marcus; Nguyen, Son; Salgado-Montes de Oca, Gonzalo et al. (2018) Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue. Sci Immunol 3:
Buggert, Marcus; Nguyen, Son; McLane, Laura M et al. (2018) Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease. PLoS Pathog 14:e1006973
Freeman, Esther E; Semeere, Aggrey; Osman, Hany et al. (2018) Smartphone confocal microscopy for imaging cellular structures in human skin in vivo. Biomed Opt Express 9:1906-1915
Martin, Jeremy W; Chen, Joseph C; Neidleman, Jason et al. (2018) Potent and rapid activation of tropomyosin-receptor kinase A in endometrial stromal fibroblasts by seminal plasma. Biol Reprod 99:336-348
Joglekar, Alok V; Liu, Zhe; Weber, Jeffrey K et al. (2018) T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable. Proc Natl Acad Sci U S A 115:1877-1882

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