The UCSF-GIVI CFAR Virology Core Laboratory provides laboratory services, consultation and training formultidisciplinary, translational research in order to advance collaborators' research programs in theprevention, treatment and understanding of HIV/AIDS. The laboratory typically supports 50 studies annually,ranging from small investigational pilot studies to large, multi-center clinical trials. Collectively, this work hassignificantly broadened our understanding of HIV disease pathogenesis, transmission and treatment.
The specific aims of the laboratory are to provide:1. Service through development and implementation of molecular diagnostic assays and analysis toolsunder strict adherence to rigorous operational procedures and quality assurance programs.2. Research through scientific leadership and laboratory resources to advance our understanding of HIV-1 transmission and correlates of protection that may lead to novel strategies for prevention. Viral replication in the context of latency and partial ARV drug suppression. The causes and consequences of ARV drug resistance. Host factors that modulate HIV replication and evolution. HIV replication and evolution in tissue compartments with a focus on transmission, antiretroviraldrug resistance and disease progression.3. Education and outreach through Mentoring and training of junior investigators and research scientists focused on translationalresearch in local, national and international settings. Consultation with research collaborators, junior scientists and community members to assist inthe interpretation and comprehension of virologic research findings.By collaborating with an increasingly strong network of multidisciplinary basic and clinical scientists, theVirology Core Laboratory is strategically and operationally poised to leverage CFAR funding to effectivelysupport translational research, and advance our understanding of HIV transmission and diseasepathogenesis, identify new and optimize the use of existing antiviral agents, and to guide vaccine design.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI027763-16
Application #
7278983
Study Section
Special Emphasis Panel (ZAI1-EC-A (J1))
Project Start
2007-07-01
Project End
2012-08-31
Budget Start
2007-07-01
Budget End
2008-08-31
Support Year
16
Fiscal Year
2007
Total Cost
$232,508
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Joglekar, Alok V; Liu, Zhe; Weber, Jeffrey K et al. (2018) T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable. Proc Natl Acad Sci U S A 115:1877-1882
Martin, Jeremy W; Chen, Joseph C; Neidleman, Jason et al. (2018) Potent and rapid activation of tropomyosin-receptor kinase A in endometrial stromal fibroblasts by seminal plasma. Biol Reprod 99:336-348
Baxi, S M; Greenblatt, R M; Bacchetti, P et al. (2018) Evaluating the association of single-nucleotide polymorphisms with tenofovir exposure in a diverse prospective cohort of women living with HIV. Pharmacogenomics J 18:245-250
Adland, Emily; Hill, Matilda; Lavandier, Nora et al. (2018) Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection. J Virol 92:
Burbelo, Peter D; Price, Richard W; Hagberg, Lars et al. (2018) Anti-Human Immunodeficiency Virus Antibodies in the Cerebrospinal Fluid: Evidence of Early Treatment Impact on Central Nervous System Reservoir? J Infect Dis 217:1024-1032
Cohen, Stephanie E; Sachdev, Darpun; Lee, Sulggi A et al. (2018) Acquisition of tenofovir-susceptible, emtricitabine-resistant HIV despite high adherence to daily pre-exposure prophylaxis: a case report. Lancet HIV :
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
Ferdin, Jana; Gori?ar, Katja; Dolžan, Vita et al. (2018) Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA. PLoS One 13:e0191613
Faust, Tyler B; Li, Yang; Bacon, Curtis W et al. (2018) The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife 7:
Wong, Cherise; Gange, Stephen J; Moore, Richard D et al. (2018) Multimorbidity Among Persons Living with Human Immunodeficiency Virus in the United States. Clin Infect Dis 66:1230-1238

Showing the most recent 10 out of 1541 publications