Funds are requested for the CFAR Developmental Core to complement the Institute's commitment to establish a major program in AIDS research. Although the objectives of the initial commitment have been attained during the current project period, DFCI plans to continue its commitment and expand the program further during the next project period. The availability of a newly-constructed research building in mid-1997 will not only provide space for new AIDS investigators but also will provide the opportunity for current CFAR members to extend their AIDS research efforts as existing space constraints are relieved. To take full advantage of the availability of the additional laboratory space and resource facilities, Developmental Funds will be utilized to enhance the CFAR research program by providing support for New Investigators to develop AIDS-related research activities, for Pilot Projects to exploit innovative ideas and technology for AIDS research, and for addressing Evolving Research Opportunities in AIDS. The CFAR Director and the CFAR Executive Committee, comprised core Directors and established AIDS investigators, will control the allocation of funds for these purposes using the effective review process which was established during the current project period. It is anticipated that a New Investigator, four Pilot Projects, and two Evolving Opportunities will be supported annually with these funds.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI028691-08
Application #
5205388
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Liu, Songtao; Fleysher, Roman; Fleysher, Lazar et al. (2010) Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T. Magn Reson Med 63:865-71
Liu, Songtao; Gonen, Oded; Fleysher, Roman et al. (2009) Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T. Magn Reson Med 62:1292-9
Ratai, Eva-Maria; Pilkenton, Sarah J; Greco, Jane B et al. (2009) In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain. BMC Neurosci 10:63
Gonen, Oded; Liu, Songtao; Goelman, Gadi et al. (2008) Proton MR spectroscopic imaging of rhesus macaque brain in vivo at 7T. Magn Reson Med 59:692-9
Ratai, Eva-Maria; Hancu, Ileana; Blezek, Daniel J et al. (2008) Automatic repositioning of MRSI voxels in longitudinal studies: impact on reproducibility of metabolite concentration measurements. J Magn Reson Imaging 27:1188-93
Liu, Songtao; Gonen, Oded; Fleysher, Lazar et al. (2008) Regional metabolite T2 in the healthy rhesus macaque brain at 7T. Magn Reson Med 59:1165-9
Li, Xing; Gold, Bert; O'hUigin, Colm et al. (2007) Unique features of TRIM5alpha among closely related human TRIM family members. Virology 360:419-33
Javanbakht, Hassan; Yuan, Wen; Yeung, Darwin F et al. (2006) Characterization of TRIM5alpha trimerization and its contribution to human immunodeficiency virus capsid binding. Virology 353:234-46
Diaz-Griffero, Felipe; Vandegraaff, Nick; Li, Yuan et al. (2006) Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1. Virology 351:404-19
Koralnik, Igor J (2006) Progressive multifocal leukoencephalopathy revisited: Has the disease outgrown its name? Ann Neurol 60:162-73

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