Abstract

The purpose of the Animal Biohazard Containment (ABC) Core Facility is to provide support for AIDS-related mouse work requiring biosafety level 2 or 3 containment. Specifically, this will include work with chimeric SCID mice transplanted with human hematolymphoid tissue. These animals are susceptible to infection with the human immunodeficiency virus type 1 (HIV-1). Long-range plans for the use of the ABS Core Facility also include studies with other pathogens, including Epstein-Barr virus, influenza virus, and other agents causing opportunistic infections. The ABS Core Facility will allow in vivo studies aimed at elucidating pathogenesis and therapy of HIV-1 as well as pathogens that play an important role in opportunistic infections seen in AIDS patients. The ABC Core Facility gives the DFCI investigators the opportunity to extend important findings made in vitro to animals and to test new hypotheses in vivo.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI028691-14
Application #
6652176
Study Section
Project Start
2002-09-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
14
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Liu, Songtao; Fleysher, Roman; Fleysher, Lazar et al. (2010) Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T. Magn Reson Med 63:865-71
Liu, Songtao; Gonen, Oded; Fleysher, Roman et al. (2009) Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T. Magn Reson Med 62:1292-9
Ratai, Eva-Maria; Pilkenton, Sarah J; Greco, Jane B et al. (2009) In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain. BMC Neurosci 10:63
Gonen, Oded; Liu, Songtao; Goelman, Gadi et al. (2008) Proton MR spectroscopic imaging of rhesus macaque brain in vivo at 7T. Magn Reson Med 59:692-9
Ratai, Eva-Maria; Hancu, Ileana; Blezek, Daniel J et al. (2008) Automatic repositioning of MRSI voxels in longitudinal studies: impact on reproducibility of metabolite concentration measurements. J Magn Reson Imaging 27:1188-93
Liu, Songtao; Gonen, Oded; Fleysher, Lazar et al. (2008) Regional metabolite T2 in the healthy rhesus macaque brain at 7T. Magn Reson Med 59:1165-9
Li, Xing; Gold, Bert; O'hUigin, Colm et al. (2007) Unique features of TRIM5alpha among closely related human TRIM family members. Virology 360:419-33
Javanbakht, Hassan; An, Ping; Gold, Bert et al. (2006) Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology 354:15-27
Diaz-Griffero, Felipe; Li, Xing; Javanbakht, Hassan et al. (2006) Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5. Virology 349:300-15
Gonzalez, R Gilberto; Greco, Jane B; He, Julian et al. (2006) New insights into the neuroimmunity of SIV infection by magnetic resonance spectroscopy. J Neuroimmune Pharmacol 1:152-9

Showing the most recent 10 out of 205 publications