The purpose of the Animal Biohazard Containment (ABC) Core Facility is to provide support for AIDS-related mouse work requiring biosafety level 2 or 3 containment. Specifically, this will include work with chimeric SCID mice transplanted with human hematolymphoid tissue. These animals are susceptible to infection with the human immunodeficiency virus type 1 (HIV-1). Long-range plans for the use of the ABS Core Facility also include studies with other pathogens, including Epstein-Barr virus, influenza virus, and other agents causing opportunistic infections. The ABS Core Facility will allow in vivo studies aimed at elucidating pathogenesis and therapy of HIV-1 as well as pathogens that play an important role in opportunistic infections seen in AIDS patients. The ABC Core Facility gives the DFCI investigators the opportunity to extend important findings made in vitro to animals and to test new hypotheses in vivo.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI028691-14
Application #
6652176
Study Section
Project Start
2002-09-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
14
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
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