Abstract

The SCID-hu Mouse/Human Chimera Core Facility is designed to provide access to state-of-the-art-mouse/human chimera technology for UCLA- affiliated AIDS investigators. This facility will provide breeding of SCID mice at a reduced rate, housing for SCID mice, and a BSL3 laboratory for manipulation and housing of chimeric mice infected with human retroviruses. Consultation on construction of mouse/human chimeras (hu- PBL-SCID and SCID-hu) is also available. In addition, there is a developmental component to this core, which has helped to established the SCID-hu mouse as an in vivo model for virus-induced pathology. This component approaches to combat AIDS, and will participate in development of a model for growth of human brain tissue in vivo. This latter system will be used to investigate mechanisms of neuropathogenesis of AIDS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI028697-04
Application #
3747054
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Daniels, Joseph; Marlin, Robert; Medline, Alex et al. (2018) Getting HIV Self-Test Kits into the Home for Young African American MSM in Los Angeles: A Qualitative Report. J Assoc Nurses AIDS Care 29:115-119
Allan-Blitz, Lao-Tzu; Herrera, M Christina; Calvo, Gino M et al. (2018) Venue-Based HIV-Testing: An Effective Screening Strategy for High-Risk Populations in Lima, Peru. AIDS Behav :
Beymer, Matthew R; Holloway, Ian W; Grov, Christian (2018) Comparing Self-Reported Demographic and Sexual Behavioral Factors Among Men Who Have Sex with Men Recruited Through Mechanical Turk, Qualtrics, and a HIV/STI Clinic-Based Sample: Implications for Researchers and Providers. Arch Sex Behav 47:133-142
Bantjes, J; Tomlinson, M; Weiss, R E et al. (2018) Non-fatal suicidal behaviour, depression and poverty among young men living in low-resource communities in South Africa. BMC Public Health 18:1195
Fehrenbacher, Anne E; Chowdhury, Debasish; Jana, Smarajit et al. (2018) Consistent Condom Use by Married and Cohabiting Female Sex Workers in India: Investigating Relational Norms with Commercial Versus Intimate Partners. AIDS Behav :
Borrell, Luisa N (2018) Editorial: Critical Race Theory: Why Should We Care about Applying It in our Research? Ethn Dis 28:215-218
Shin, S S; Modongo, C; Zetola, N M et al. (2018) High rates of exposure to tuberculosis patients among HIV-infected health care workers in Botswana. Int J Tuberc Lung Dis 22:366-370
Airhihenbuwa, Collins O; Ford, Chandra L (2018) Editorial: Critical Race Theory - We Are all Others. Ethn Dis 28:219-222
Chin, Chee Jia; Li, Suwen; Corselli, Mirko et al. (2018) Transcriptionally and Functionally Distinct Mesenchymal Subpopulations Are Generated from Human Pluripotent Stem Cells. Stem Cell Reports 10:436-446
Adachi, Kristina; Xu, Jiahong; Ank, Bonnie et al. (2018) Congenital CMV and HIV Perinatal Transmission. Pediatr Infect Dis J :

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