The purpose of the Clinical Research Core is to facilitate investigations of HIV infection and disease pathogenesis that require the use of human specimens. The Clinical Research Core builds upon the success of the previous CFAR Pediatric HIV Specimen Core by expanding the scope of operations to include infrastructure for acquisition of adult AIDS clinical specimens. Dr. William T. Shearer will be Core Director and Dr. Howard M. Rosenblatt (previous Director of the Pediatric Specimen Core) will be Assistant Director. New to this core is the installation of an adult ACTG subunit site at Baylor College of Medicine by Dr. Richard Pollard, Principal Investigator of the ACTG site at the University of Texas Medical Branch in Galveston. Up to 100 adult patients will be enrolled in the BCM ACTG subsite in the first year of operation. The newly funded General Clinical Research Center at The Methodist Hospital, Baylor's principal adult teaching hospital, will be able to enroll these patients into multicenter ACTG clinical protocols and obtain specimens. Also, as additional sources, the Thomas Street Clinic, the VA Hospital, and the Montrose Clinic will provide adult HIV specimens to basic researchers through the facilities of the CFAR Clinical Research Core. Creation of this core was prompted by the CFAR experience of the past 4 years and by the needs assessment performed during the pla:ning process for the CFAR renewal. This core will continue to supply pediatric HW specimens to basic researchers at Baylor and in other research institutions. Addition of the adult patient component to the Baylor CFAR greatly expands its ability to support basic and clinical HIV research and, eventually, patient care.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036211-07
Application #
6355556
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
Budget End
Support Year
7
Fiscal Year
2000
Total Cost
$108,748
Indirect Cost
Name
Baylor College of Medicine
Department
Type
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Newton, Jared M; Hanoteau, Aurelie; Sikora, Andrew G (2018) Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors. J Vis Exp :
Wang, Changjun; Zaheer, Mahira; Bian, Fang et al. (2018) Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci 19:
Spencer, Jennifer L; Lahon, Anismrita; Tran, Linda L et al. (2018) Replication of Zika Virus in Human Prostate Cells: A Potential Source of Sexually Transmitted Virus. J Infect Dis 217:538-547
Hong, M J; Gu, B H; Madison, M C et al. (2018) Protective role of ?? T cells in cigarette smoke and influenza infection. Mucosal Immunol 11:894-908
Madan, Simran; Kron, Bettina; Jin, Zixue et al. (2018) Arginase overexpression in neurons and its effect on traumatic brain injury. Mol Genet Metab 125:112-117
Hsu, Joanne I; Dayaram, Tajhal; Tovy, Ayala et al. (2018) PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell 23:700-713.e6
Misra, Anisha; Gleeson, Emile; Wang, Weiming et al. (2018) Glycosyl-Phosphatidylinositol-Anchored Anti-HIV Env Single-Chain Variable Fragments Interfere with HIV-1 Env Processing and Viral Infectivity. J Virol 92:
Byrd, Tiara T; Fousek, Kristen; Pignata, Antonella et al. (2018) TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Cancer Res 78:489-500
Nabekura, Tsukasa; Chen, Zhiying; Schroeder, Casey et al. (2018) Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection. J Immunol 200:3420-3428
Haller, Meade; Au, Jason; O'Neill, Marisol et al. (2018) 16p11.2 transcription factor MAZ is a dosage-sensitive regulator of genitourinary development. Proc Natl Acad Sci U S A 115:E1849-E1858

Showing the most recent 10 out of 690 publications