Abstract

The overall objectives of the Virology Core Laboratory are to provide comprehensive virologic tests and services relevant to HIV research, to make available its specialized BSL2/3 laboratory facilities to HW researchers, and to develop new virologic tests that may be useful in clinical and basic research. Major core services include: (1) assays of HW infectivity by means of quantitative micrococultures, (2) assays of HW1 RNA and DNA, (3) characterization of HIV quasispecies, (4) phenotypic characterization of drug resistance and of syncytium-inducing capacity, and (5) processing, storage and shipment of blood specimens and other biological samples from patients with HIV. The core will also provide training and technical advice to researchers interested in developing sophisticated virologic procedures for their HW projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036211-08
Application #
6499754
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2001-09-01
Project End
2002-08-31
Budget Start
Budget End
Support Year
8
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Spencer, Jennifer L; Lahon, Anismrita; Tran, Linda L et al. (2018) Replication of Zika Virus in Human Prostate Cells: A Potential Source of Sexually Transmitted Virus. J Infect Dis 217:538-547
Hong, M J; Gu, B H; Madison, M C et al. (2018) Protective role of ?? T cells in cigarette smoke and influenza infection. Mucosal Immunol 11:894-908
Madan, Simran; Kron, Bettina; Jin, Zixue et al. (2018) Arginase overexpression in neurons and its effect on traumatic brain injury. Mol Genet Metab 125:112-117
Hsu, Joanne I; Dayaram, Tajhal; Tovy, Ayala et al. (2018) PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell 23:700-713.e6
Misra, Anisha; Gleeson, Emile; Wang, Weiming et al. (2018) Glycosyl-Phosphatidylinositol-Anchored Anti-HIV Env Single-Chain Variable Fragments Interfere with HIV-1 Env Processing and Viral Infectivity. J Virol 92:
Byrd, Tiara T; Fousek, Kristen; Pignata, Antonella et al. (2018) TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Cancer Res 78:489-500
Nabekura, Tsukasa; Chen, Zhiying; Schroeder, Casey et al. (2018) Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection. J Immunol 200:3420-3428
Haller, Meade; Au, Jason; O'Neill, Marisol et al. (2018) 16p11.2 transcription factor MAZ is a dosage-sensitive regulator of genitourinary development. Proc Natl Acad Sci U S A 115:E1849-E1858
Tan, Qiumin; Brunetti, Lorenzo; Rousseaux, Maxime W C et al. (2018) Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma. Proc Natl Acad Sci U S A 115:E1511-E1519
Bayrer, James R; Wang, Hongtao; Nattiv, Roy et al. (2018) LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun 9:4055

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