Core A ? Administrative Core The CWRU/UH CFAR Administrative Core is responsible for driving the direction of the HIV/AIDS research at our institutions while at the same time responding to evolving research needs of CFAR investigators. The Administrative Core provides the leadership and organizational structure to coordinate, support and enhance the efforts of the 102 Full members, 53 Associate members, who are students, postdoctoral fellows and research associates and 21 International members from Uganda, South Africa, and Britain that make up the CFAR. Major scientific strengths leveraged by the CWRU/UH CFAR include international research based on our 26 year collaboration with colleagues in Uganda, immune pathogenesis, basic virology and Cure research, and clinical trials. The Administrative Core has developed a thoughtful and responsive Strategic Planning process developed with input from CFAR members and institutional leaders. Implementation of the Strategic Plan includes strengthening and realigning the Cores, using institutional funds to invest in key new technologies for the Cores, effective fiscal controls for the CFAR, outreach programs to inform CFAR investigators and the local community of recent progress and events, and methods to foster cross-CFAR linkages.
The Specific Aims for the Case CWRU/CFAR Administrative Core A are: To coordinate a rigorous annual review and scientific planning process and to implement the plan through enhancement of Core services, recruitment, and stimulating new research activities. To leverage institutional support to enhance HIV/AIDS research at our institutions. To support our long-standing commitment to HIV/AIDS research in Uganda. The CFAR operates one of the most advanced scientific laboratories in sub-Saharan Africa. To stimulate training activities throughout the CFAR. To improve communications throughout the CFAR and oversee Biosafety activities. To participate in collaborative research efforts within the national CFAR network. In summary, the Administrative Core provides effective leadership for the CFAR by using its resources to generate and implement a well-conceived strategic plan. When unexpected events happen, due to Faculty recruitment or turnover, or changes in the HIV research agenda due to new scientific advances, the Core has demonstrated that it can respond in a rapid and effective fashion.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036219-24
Application #
9468333
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
24
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Kalayjian, Robert C; Albert, Jeffrey M; Cremers, Serge et al. (2018) Women have enhanced bone loss associated with phosphaturia and CD4+ cell restoration during initial antiretroviral therapy. AIDS 32:2517-2524
AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786
Mbonye, Uri; Wang, Benlian; Gokulrangan, Giridharan et al. (2018) Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation. J Biol Chem 293:10009-10025
Sayin, Ismail; Radtke, Andrea J; Vella, Laura A et al. (2018) Spatial distribution and function of T follicular regulatory cells in human lymph nodes. J Exp Med 215:1531-1542
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Martinez, Leonardo; Shen, Ye; Handel, Andreas et al. (2018) Effectiveness of WHO's pragmatic screening algorithm for child contacts of tuberculosis cases in resource-constrained settings: a prospective cohort study in Uganda. Lancet Respir Med 6:276-286
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Kityo, Cissy; Makamdop, Krystelle Nganou; Rothenberger, Meghan et al. (2018) Lymphoid tissue fibrosis is associated with impaired vaccine responses. J Clin Invest 128:2763-2773
Wiredja, Danica D; Tabler, Caroline O; Schlatzer, Daniela M et al. (2018) Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells. Retrovirology 15:44
Oliveira, Vitor H F; Perazzo, Joseph D; Josephson, Richard A et al. (2018) Association Between the 6-Minute Walk Test Distance and Peak Cardiorespiratory Fitness Among People Living with HIV Varies by Fitness Level. J Assoc Nurses AIDS Care 29:775-781

Showing the most recent 10 out of 539 publications