Abstract

The major goals of the Developmental Core are twofold. First, to attract new investigators to HIV/AIDS research by providing seed money in the form of """"""""New Investigator Awards"""""""". Second, the Core will support pilot projects which involve synergistic, multi-disciplinary collaborations amongst the CF-CFAR members. These projects will receive $40,000 to 60,00 in direct costs for one year. This may be used for salary support, technical support or supplies. The four planned first year awards, as determined by the Core director Dr. Jeremy Luban and the Core sub-committee include projects by; new investigator Mark Muesing (ADARC) investigating the genetics and biology of HIV-1 integrase; new investigator Steve Greenberg (Columbia) probing the association of apoptosis and inflammation, new investigator Gerald Siu (Columbia) linking HHV-6 and transcriptional regulation of CD4, and finally new investigator Kathryn Calame (Columbia) investigating the association of transcriptional binding sites with HIV-1 replication in primary monocytes/macrophages. Project funding for subsequent years will be decided by the Core sub-committee headed by Dr. Luban with criteria for selection including; scientific merit, impact on both HIV/AIDS and the CR-CFAR, and conforming to the original intent of the Developmental Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI042848-02
Application #
6201417
Study Section
Project Start
1999-09-01
Project End
2000-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Aaron Diamond AIDS Research Center
Department
Type
DUNS #
786658872
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Mukhopadhyay, Madhura; Galperin, Moran; Patgaonkar, Mandar et al. (2017) DNA Vaccination by Electroporation Amplifies Broadly Cross-Restricted Public TCR Clonotypes Shared with HIV Controllers. J Immunol 199:3437-3452
Collins, Pamela Y; Kondos, Leeza; Pillai, Aravind et al. (2016) Passive Suicidal Ideation and Community Mental Health Resources in South Africa. Community Ment Health J 52:541-50
Markowitz, Martin; Evering, Teresa H; Garmon, Donald et al. (2014) A randomized open-label study of 3- versus 5-drug combination antiretroviral therapy in newly HIV-1-infected individuals. J Acquir Immune Defic Syndr 66:140-7
Mantell, Joanne E; West, Brooke S; Sue, Kimberly et al. (2011) Health care providers: a missing link in understanding acceptability of the female condom. AIDS Educ Prev 23:65-77
Hoffman, Susie; Higgins, Jenny A; Beckford-Jarrett, Sharlene T et al. (2011) Contexts of risk and networks of protection: NYC West Indian immigrants' perceptions of migration and vulnerability to sexually transmitted diseases. Cult Health Sex 13:513-28
Zhukovsky, Mikhail A; Basmaciogullari, Stéphane; Pacheco, Beatriz et al. (2010) Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes. PLoS One 5:e13249
Coovadia, Hoosen; Mantell, Joanne E (2010) Adolescents and HIV in sub-Saharan Africa: a timely issue and missed opportunity. Clin Infect Dis 51:852-4
Flacher, Vincent; Tripp, Christoph H; Stoitzner, Patrizia et al. (2010) Epidermal Langerhans cells rapidly capture and present antigens from C-type lectin-targeting antibodies deposited in the dermis. J Invest Dermatol 130:755-62
Yuan, Wen; Li, Xing; Kasterka, Marta et al. (2009) Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodies. AIDS Res Hum Retroviruses 25:319-28
Kassa, Aemro; Madani, Navid; Schön, Arne et al. (2009) Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain. J Virol 83:8364-78

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