Core D: HIV and Women's CoreThe HIV and Women's Core has continued to develop collaborations within the Lifespan/Tufts/Browncommunity including the Brown National Center of Excellence in Women's Health and among other nationalCFARs to develop translational research in the area of HIV and Women and 'hard to reach populations'.The Core aims to encourage and assist CFAR investigators to develop studies related to HIV and womencovering a broad range of areas (in domestic as well as international sites); assist in the submission ofdevelopmental grant applications and independent grant applications related to HIV and women; to provideresources instrumental in the collection, cataloging and maintenance of a repository of blood and genitaltract secretions; to continue to provide training in genital tract collection for virologic and immunologicstudies; to provide training and resources to enhance HIV research among 'hard to reach' communities,such as active substance users, corrections, and impoverished inner city neighborhoods; and to enhance therecruitment of female and minority researchers in the area of HIV/AIDS research.
Specific Aims of the Core (Benchmarks):! )To assess the prevalence and incidence of cervical and analHPV; cervical and anal dysplasia/cancer among HIV-infected women and to assess the safety, tolerability,immunogenicity of HPV vaccines among HIV-infected women.2)To continue to assess the factors thatimpact HIV shedding and development of resistance in the female genital tract particularly asymptomaticHSV-2 infection and bacterial vaginosis.3)To develop a community based intervention to improve adherenceto antiretroviral therapy among men and women leaving correctional setting and among pregnant/postpartumwomen. 4) To provide training and expertise on community based intervention, particularly modifieddirectly observed therapy to at least three NIH funded programs in other sites. 5) To evaluate the costeffectiveness of community based modified directly observed therapy for HAART experienced substanceusers that are failing antiretroviral treatment. 6) To improve HIV detection/testing strategies amongmarginalized communities with linkage to care, particularly in inner city emergency departments, jails, andlower income colleges and universities.
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