Abstract

application): This application proposes to re-establish a CFAR at Johns Hopkins University (JHU), with the goal of fostering collaborative and innovative AIDS research at JHU. To this end, the proposed CFAR will support collection of clinical specimens from a well-characterized patient population (Clinical Core); a pilot project program that would increase the ability of productive investigators to pursue high-risk, high impact ideas (Developmental Core); key service Core facilities (Flow Cytometry and Cell Sorting Core, Monoclonal Antibody Core); and centralized administrative operations designed to disseminate key scientific information and increase intellectually fruitful contact among AIDS researchers (Administrative Core). The Administrative Core will include representatives of all disciplines of HIV/AIDS research at JHU and will regularly review the cost-effectiveness of all CFAR-supported activities, as compared to other Cores and programs that the CFAR could support. Initially, four critical aspects of HIV infection will be emphasized: 1) pathogenesis, 2) latent HIV infection, 3) immune restoration, and 4) prevention. Overall, the specific aims of the CFAR will be to disseminate scientific information among investigators, foster innovative and collaborative research, bring new investigators into HIV/AIDS research, and increase the profile of HIV/AIDS research at Johns Hopkins University.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI042855-04
Application #
6656824
Study Section
Special Emphasis Panel (ZAI1-EWS-A (J1))
Program Officer
Young, Janet M
Project Start
2000-09-29
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
4
Fiscal Year
2003
Total Cost
$1,451,207
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Noguchi, Lisa M; Montgomery, Elizabeth T; Biggio, Joseph R et al. (2016) Detectable Tenofovir Levels in Breast-Feeding Infants of Mothers Exposed to Topical Tenofovir. Antimicrob Agents Chemother 60:5616-9
Yuan, Ming; Eberhart, Charles G; Kai, Mihoko (2014) RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation. Oncotarget 5:2820-6
Hulbert, Alicia; Hooker, Craig M; Keruly, Jeanne C et al. (2014) Prospective CT screening for lung cancer in a high-risk population: HIV-positive smokers. J Thorac Oncol 9:752-9
Iyengar, Sujatha; Schwartz, David H (2012) Acquisition of CD4-dependence by CD4-independent SIV passaged in human peripheral blood mononuclear cells. Retrovirology 9:61
Louissaint, Nicolette A; Nimmagadda, Sridhar; Fuchs, Edward J et al. (2012) Distribution of cell-free and cell-associated HIV surrogates in the colon after simulated receptive anal intercourse in men who have sex with men. J Acquir Immune Defic Syndr 59:10-7
Ndip, Lucy M; Biswas, Hope H; Nfonsam, Landry E et al. (2011) Risk factors for African tick-bite fever in rural central Africa. Am J Trop Med Hyg 84:608-13
Durand, Christine M; O'Connell, Karen A; Apuzzo, Linda G et al. (2010) HIV-1 Gag evolution in recently infected human leukocyte antigen-B*57 patients with low-level viremia. AIDS 24:2405-8
Zhou, Jiangbing; Zhang, Hao; Gu, Peihua et al. (2009) Cancer stem/progenitor cell active compound 8-quinolinol in combination with paclitaxel achieves an improved cure of breast cancer in the mouse model. Breast Cancer Res Treat 115:269-77
Hendrix, Craig W; Cao, Ying Jun; Fuchs, Edward J (2009) Topical microbicides to prevent HIV: clinical drug development challenges. Annu Rev Pharmacol Toxicol 49:349-75
Ocama, P; Nambooze, S; Opio, C K et al. (2009) Trends in the incidence of primary liver cancer in Central Uganda, 1960-1980 and 1991-2005. Br J Cancer 100:799-802

Showing the most recent 10 out of 38 publications