The activities of the International Core (Core I) are centered in Botswana, a country that serves as a remarkable success story for confronting the HIV/AIDS epidemic in sub-Saharan Africa. Core I has made impressive advances in performing HIV/AIDS research that is relevant to the people of Botswana and that has advanced knowledge of the global epidemic. Markers of our accomplishments include the large number of NIH and Foundation grants in HIV/AIDS that Core I investigators have secured for their research in Botswana during the current funding cycle, the substantial growth in number and quality of publications, and the success at attaining national and international recognition for their research by junior faculty located at Penn and by junior faculty who are residing fulltime in Botswana as part of the Botswana-UPenn Partnership (BUP) program (an extension of Penn's campus in Botswana). The BUP has robust clinical and educational programs focused on providing care and technical assistance related to HIV and its complications, HIV-TB co-infection, multidrug resistant TB, cervical cancer screening in HIV infected women using the

Public Health Relevance

The Penn CFAR International Core has developed vibrant and highly productive research programs in collaboration with the Government of Botswana and the University of Botswana School of Medicine. The research focuses on HIV and its complications, tuberculosis, screening for cervical cancer in HIV infected women, and use of cell phones to improve health care delivery. The impact is substantial as Penn scientists partner with researchers in country to address some ofthe most pressing issues ofthe HIV/AIDS epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI045008-17
Application #
8847273
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
17
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Fraietta, Joseph A; Nobles, Christopher L; Sammons, Morgan A et al. (2018) Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells. Nature 558:307-312
Kelly, Matthew S; Surette, Michael G; Smieja, Marek et al. (2018) Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana. Pediatr Infect Dis J 37:1176-1183
Chitre, Avantika S; Kattah, Michael G; Rosli, Yenny Y et al. (2018) A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog 14:e1006806
Milligan, Michael G; Bigger, Elizabeth; Abramson, Jeremy S et al. (2018) Impact of HIV Infection on the Clinical Presentation and Survival of Non-Hodgkin Lymphoma: A Prospective Observational Study From Botswana. J Glob Oncol :1-11
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Uzzan, Mathieu; Tokuyama, Minami; Rosenstein, Adam K et al. (2018) Anti-?4?7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals. Sci Transl Med 10:
Vadrevu, Surya Kumari; Trbojevic-Akmacic, Irena; Kossenkov, Andrew V et al. (2018) Frontline Science: Plasma and immunoglobulin G galactosylation associate with HIV persistence during antiretroviral therapy. J Leukoc Biol 104:461-471
Loy, Dorothy E; Plenderleith, Lindsey J; Sundararaman, Sesh A et al. (2018) Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites. Proc Natl Acad Sci U S A 115:E8450-E8459

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