The Viral and Rickettsial Disease Laboratory (VRDL) of the California Department of Health Services (DHS) will participate in the NCCFAR both as a service provider and as a user of the services that will be provided through the NCCFAR structure. The VRDL will serve as the Virology-Immunology Core for the NCCFAR and will provide a comprehensive array of HIV-related virologic and immunologic assays, which can be utilized by other NCCFAR members, to support pathogenesis/natural history research and/or clinical trials of anti-viral treatment, vaccines, or immune modulation/restoration therapy. This service will be monitored regularly and periodic outcomes evaluation will be performed. We anticipate that the Clinical Investigation Core will be a major user of these services. The VRDL will also serve as an HIV/AIDS laboratory-training center through our participation in the Fogarty International AIDS training center at UC Berkeley, which will also be a component part of the NCCFAR. The VRDL has a 14-year history of involvement in many aspects of HIV/AIDS biomedical research, including prospective natural history cohort studies, lab support for clinical trials of HIV prevention (both vaccine and non-vaccine), clinical trials of immune modulation, and most recently, pre-clinical vaccine development. We also anticipate the need to conduct vaccine studies in non-human primates and the possibility of conducting Phase I human safety trials of candidate vaccine formulations within the next several years. Since VRDL/CDHS does not have a primate facility, a medical center, or participant recruitment capacity, the availability of these resources through the NCCFAR will result in a dramatic enhancement of the ability to conduct VRDL-initiated clinical trials of treatment and vaccines. Finally, our natural history and pathogenesis research will also be enhanced through the research collaborations that the NCCFAR is designed to foster.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI049366-02
Application #
6654021
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2002-09-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
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