Under the direction of Dr. John D. Altman, the mission of Core H, the Emory CFAR Immunology CoreLaboratory (ICL), is to provide the Emory community with the highest quality assessments of immunologicalfunction necessary for the study of the pathogenesis, treatment, and prevention of immunodeficiency virusinfections in humans and non-human primates. The ICL will achieve this mission through the followingSpecific Aims:1. Develop and perform optimized, standardized, and validated assays of cellular immune function invaccinated subjects, in HIV-infected humans, and in SIV-infected non-human primates (NHP);2. Create a repository of cryopreserved PBMC from naive (off-study) monkeys from the YerkesPrimate Research Center, thereby providing CFAR investigators with access to esse'ntial negative controlsamples for assay development and validation.3. Achieve economies of scale through the provision of immunological reagent resources shared bymultiple independent laboratories;4. Maintain a CFAR Flow Cytometry Core, for the purpose of providing members of the Emory CFAR, andthe larger AIDS research community, with the highest quality flow cytometry data and cell sortingservices available, including handling of biohazardous samples;5. Promote immunological assay education and training opportunities for CFAR investigators, theAIDS research community in Atlanta, and national and international AIDS investigators.Through these Aims, the ICL will enable all Emory CFAR investigators to take advantage of innovative andpowerful modern approaches to quantitative analysis of innate and acquired humoral and cell-mediatedimmunity that have been developed by individual Emory investigators and scientists elsewhere. Accuratecharacterization of cell-mediated immune responses is essential for guiding preclinical vaccine development,for determining possible correlates of vaccine efficacy in preclinical and clinical trials, and for betterunderstanding AIDS pathogenesis.
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