University of North Carolina CFAR Core D Virology Laboratory;Director: Susan A Fiscus, Ph.D., Professor of Microbiology &Immunology;Associate Director: Leslie Petch, Ph.D. The Virology Core Laboratory provides laboratory support and facilitates basic AIDS research to CFAR investigators at the University of North Carolina (UNC), Family Health International (FHI), and Research Triangle Institute (RTI). Specifically the Virology Core Laboratory is a group of established investigators and very experienced technologists who provide a high level of expertise in state of the art clinical and molecular assays for culturing, quantitating, and sequencing HIV. In addition we provide institutional infrastructure such as a repository for storage of biological specimens in conjuction with the Immunology and Clincial Cores, current CDC-USPHS permit for importing HIV+ specimens from foreign countries, and a BSL-3 facility. The UNC Core D Lab provides scientific leadership locally to six CFAR working groups, nationally to the AACTG, PACTG, HPTN, and ATN, and internationally to CIPRA and the CDC-GAP. We stimulate collaboration in interdisciplinary and translational research by helping numerous CFAR investigators from a wide variety of UNC CFAR departments or institutions;strengthen capacity in Malawi, Democratic Republic of Congo, and South Africa, among others;foster scientific communication, contributing to 107 abstracts and 127 peerreviewed manuscripts over the past five years;sponsor training opportunities to numeorus foreign and domestic investigators and study coodinators;and facilitate technology transfer and development through promotion of scientific collaborations between UNC and Gen-Probe, CavidiTech, and Perkin-Elmer. Major accomplishments over the past five years have been in the fields of acute HIV infection and prevention of mother to child transmission (CDC-Breastfeeding and Nutrition Study, CDC-Global AIDS Project, NVAZ). Other major studies that are supported the UNC CFAR include: Adult AIDS Clinical Trials Group, HIV Prevention Trial Unit in Malawi, Fogarty international training grant, and grants dealing with HIV in compartments.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI050410-13
Application #
8080830
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
13
Fiscal Year
2010
Total Cost
$291,395
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Martin, Maureen P; Naranbhai, Vivek; Shea, Patrick R et al. (2018) Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. J Clin Invest 128:1903-1912
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Fitzpatrick, Thomas; Zhou, Kali; Cheng, Yu et al. (2018) A crowdsourced intervention to promote hepatitis B and C testing among men who have sex with men in China: study protocol for a nationwide online randomized controlled trial. BMC Infect Dis 18:489
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Fitzpatrick, Thomas; Pan, Stephen W; Tang, Weiming et al. (2018) HBV and HCV test uptake and correlates among men who have sex with men in China: a nationwide cross-sectional online survey. Sex Transm Infect 94:502-507
Rucinski, Katherine B; Rutstein, Sarah E; Powers, Kimberly A et al. (2018) Sustained Sexual Behavior Change After Acute HIV Diagnosis in Malawi. Sex Transm Dis 45:741-746
Mathews, Allison; Farley, Samantha; Hightow-Weidman, Lisa et al. (2018) Crowdsourcing and community engagement: a qualitative analysis of the 2BeatHIV contest. J Virus Erad 4:30-36
Chinula, Lameck; Nelson, Julie A E; Wiener, Jeffrey et al. (2018) Effect of the depot medroxyprogesterone acetate injectable and levonorgestrel implant on HIV genital shedding: a randomized trial. Contraception 98:193-198
Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504
Masa, Rainier; Chowa, Gina; Nyirenda, Victor (2018) Chuma na Uchizi: A Livelihood Intervention to Increase Food Security of People Living with HIV in Rural Zambia. J Health Care Poor Underserved 29:349-372

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