Abstract

The Molecular Biology and Genomics Core of the HU CFAR will build upon the combined strengths of the pre-existing Virology/Molecular Biology core and the Genomics program (initiated in 2007). The primary goal of the new Genomics core is to enable CFAR investigators by providing access to and support with state-ofthe- art genomic technologies (including but not limited to viral sequencing, host genomics, gene expression profiling) for HIV/AIDS research projects. We will do this by offering guidance to those who wish to initiate genomics projects or incorporate genomic techniques into their research, and by referring investigators to key scientists with relevant expertise in the local genomics community, including those at the Broad Institute of Harvard and MIT. In addition, we will continue to provide services that have been offered previously at the Dana-Farber Cancer Institute Molecular Biology Core Facilities (through the pre-existing HU CFAR Virology/Molecular Biology core). Dr Paul de Bakker (currently HU CFAR Genomics Program Director) will be the new core director.

Public Health Relevance

Genetics and genomics have become indispensable tools to develop a better understanding of HIV biology, specifically, how HIV interacts with the immune system, how it exhausts the immune system, and ultimately, how it leads to AIDS. We are allowing Harvard scientists to access these tools and maximize the impact of their research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI060354-06
Application #
7685010
Study Section
Special Emphasis Panel (ZAI1-SV-A (J3))
Project Start
2009-08-11
Project End
2014-07-31
Budget Start
2009-07-01
Budget End
2010-07-31
Support Year
6
Fiscal Year
2009
Total Cost
$318,642
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
082359691
City
Cambridge
State
MA
Country
United States
Zip Code
02138

  Publications

Alvi, Raza M; Neilan, Anne M; Tariq, Noor et al. (2018) Protease Inhibitors and Cardiovascular Outcomes in Patients With HIV and Heart Failure. J Am Coll Cardiol 72:518-530
Rogers, Brooke G; Mendez, Noelle A; Mimiaga, Matthew J et al. (2018) ""I Wasn't in My Right Mind"": Qualitative Findings on the Impact of Alcohol on Condom Use in Patients Living with HIV/AIDS in Brazil, Thailand, and Zambia (HPTN 063). Int J Behav Med :
Looby, Sara E; Psaros, Christina; Raggio, Greer et al. (2018) Association between HIV status and psychological symptoms in perimenopausal women. Menopause 25:648-656
Bassett, Ingrid V; Xu, Ai; Govere, Sabina et al. (2018) Contraception and PrEP in South African Hair Salons: Owner, Stylist, and Client Views. J Acquir Immune Defic Syndr 79:e78-e81
Shapiro, Adrienne E; Hong, Ting; Govere, Sabina et al. (2018) C-reactive protein as a screening test for HIV-associated pulmonary tuberculosis prior to antiretroviral therapy in South Africa. AIDS 32:1811-1820
Clayton, Kiera L; Collins, David R; Lengieza, Josh et al. (2018) Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Nat Immunol 19:475-486
Ojikutu, Bisola O; Srinivasan, Sumeeta; Bogart, Laura M et al. (2018) Mass incarceration and the impact of prison release on HIV diagnoses in the US South. PLoS One 13:e0198258
Bengtson, Angela M; Pence, Brian W; Eaton, Ellen F et al. (2018) Patterns of efavirenz use as first-line antiretroviral therapy in the United States: 1999-2015. Antivir Ther 23:363-372
North, Crystal M; Muyanja, Daniel; Kakuhikire, Bernard et al. (2018) Brief Report: Systemic Inflammation, Immune Activation, and Impaired Lung Function Among People Living With HIV in Rural Uganda. J Acquir Immune Defic Syndr 78:543-548
Bebell, Lisa M; Ngonzi, Joseph; Siedner, Mark J et al. (2018) HIV Infection and risk of postpartum infection, complications and mortality in rural Uganda. AIDS Care 30:943-953

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