The Duke University CFAR Clinical Core will play a central role in coordinating all HIV/AIDS-related human subjects research. The major goals of the Clinical Core are to expand international HIV/AIDS research, develop new translational research projects into clinical trials, attract new investigators to HlV-related clinical research, ensure the quality of all CFAR-supported clinical investigations, provide critical administrative and logistical support to CFAR investigators, expand the clinical databases of CFAR members, and ensure the participation of research subjects who reflect diversity in the infected population. The goals are intimately related to the Duke University CFAR objectives for the next 5 years and as a result, the Clinical Core has extensive relationships with other CFAR Cores and Programs. By coordinating access to domestic and international populations of HFV-infected subjects, the Clinical Core will ensure the efficient conduct of rigorous and ethically sound clinical investigations. Expanding international HIV/AIDS research opportunities will stimulate and enhance the CFAR scientific agenda. Translational research is a hallmark of the Clinical Core, and recent studies of C4-V3 synthetic peptides and T-1249 have taken a novel immunogen and an antiretroviral compound from the laboratories of Duke basic science CFAR investigators to the bedside. Restoring support for the CFAR Clinical Core will add critical value to the conduct of HIV/AIDS investigation at Duke University.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI064518-02
Application #
7310274
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
2
Fiscal Year
2006
Total Cost
$265,611
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Cherenack, Emily M; Sikkema, Kathleen J; Watt, Melissa H et al. (2018) Avoidant Coping Mediates the Relationship Between Self-Efficacy for HIV Disclosure and Depression Symptoms Among Men Who Have Sex with Men Newly Diagnosed with HIV. AIDS Behav 22:3130-3140
Sikkema, Kathleen J; Mulawa, Marta I; Robertson, Corne et al. (2018) Improving AIDS Care After Trauma (ImpACT): Pilot Outcomes of a Coping intervention Among HIV-Infected Women with Sexual Trauma in South Africa. AIDS Behav 22:1039-1052
Blasi, Maria; Negri, Donatella; LaBranche, Celia et al. (2018) IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells. Commun Biol 1:134
Collins, Lauren F; Chan, Austin; Zheng, Jiayin et al. (2018) Direct-Acting Antivirals Improve Access to Care and Cure for Patients With HIV and Chronic HCV Infection. Open Forum Infect Dis 5:ofx264
Wills, Saintedym; Hwang, Kwan-Ki; Liu, Pinghuang et al. (2018) HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis. J Virol 92:
Watt, Melissa H; Knippler, Elizabeth T; Knettel, Brandon A et al. (2018) HIV Disclosure Among Pregnant Women Initiating ART in Cape Town, South Africa: Qualitative Perspectives During the Pregnancy and Postpartum Periods. AIDS Behav 22:3945-3956
Clement, Meredith E; Okeke, Nwora L; Munn, Terry et al. (2018) Partnerships Between a University-Affiliated Clinic and Community-Based Organizations to Reach Black Men Who Have Sex With Men for PrEP Care. J Acquir Immune Defic Syndr 77:e25-e27
Naggie, Susanna; Swiderska-Syn, Marzena; Choi, Steve et al. (2018) Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection. Open Forum Infect Dis 5:ofy138
Ferrari, Guido (2018) Tandem bispecific broadly neutralizing antibody - a novel approach to HIV-1 treatment. J Clin Invest 128:2189-2191
Dai, Joanne; Luftig, Micah A (2018) Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation. J Immunol 200:1727-1736

Showing the most recent 10 out of 488 publications